Literature summary for 3.1.1.2 extracted from

Nguyen, S.D.; Hung, N.D.; Cheon-Ho, P.; Ree, K.M.; Dai-Eun, S.
Oxidative inactivation of lactonase activity of purified human paraoxonase 1 (PON1) (2009), Biochim. Biophys. Acta, 1790, 155-160.

Search for more literature for 3.1.1.2

Inhibitors

Inhibitors	Comment	Organism	Structure
ascorbate	0.5 mM inhibits by ca. 19%. Ascorbate/Cu2+ (0.5 mM/0.001 mM) system shows ca. 91% inactivation	Homo sapiens
Cu2+	0.001 mM inhibits by ca. 13%. Ascorbate/Cu2+ (0.5 mM/0.001 mM) system shows ca. 91% inactivation. Ascorbate/Fe2+ (0.5 mM/0.002 mM) system shows ca. 51% inactivation after 30 min	Homo sapiens
Fe2+	ascorbate/Fe2+ (0.5 mM/0.002 mM) system shows ca. 51% inactivation after 30 min	Homo sapiens
additional information	1 mM 3-morpholinosydnoimine, 0.002 mM Fe2+ or 0.01 mM Mn2+, Co2+, Zn2+ cause no significant loss of activity	Homo sapiens
sodium hypochlorite	at 1 mM causes approximately 15% decrease in activity, at 1 mM and in the presence of PBS buffer causes approximately 76% decrease in activity	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	required for the catalysis	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
45000	-	x * 45000, SDS-PAGE	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
by different types of chromatographies	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
plasma	-	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
721	-	-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
phenyl acetate + H2O	-	Homo sapiens	phenol + acetate	-	?

Subunits

Subunits	Comment	Organism
?	x * 45000, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
arylesterase	-	Homo sapiens

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Release 2023.1 (January 2023)