Application | Comment | Organism |
---|---|---|
medicine | baseline and stimulated ARE activity is significantly lower in patients with chronic liver disease than in controls, serum ARE activity can be a suitable biomarker for the evaluation of the presence and severity of chronic liver damage | Homo sapiens |
medicine | serum ARE activity may be a suitable biomarker for identifying the presence and severity of chronic liver injury | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
serum | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl acetate + H2O | - |
Homo sapiens | 4-nitrophenol + acetate | - |
? | |
phenyl acetate + H2O | - |
Homo sapiens | phenol + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ARE | - |
Homo sapiens |
arylesterase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | baseline and stimulated paraoxonase (PON1) and ARE activities are significantly lower in patients with chronic liver disease (by 32%) than in controls. ARE activity is significantly decreased (by 55%) in liver cirrhosis patients. ARE activity is significantly lower (by 35%) in cirrhotic patients compared with the chronic hepatitis group. ARE/high-density lipoprotein and the ARE/apolipoprotein A1 ratios are significantly reduced in patients with chronic hepatitis compared with controls. Similarly, the ARE/high-density lipoprotein and the ARE/apolipoprotein A1 ratios are significantly lower in patients with cirrhosis than in controls | Homo sapiens |