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Literature summary for 3.1.1.2 extracted from

  • Keskin, M.; Dolar, E.; Dirican, M.; Kiyici, M.; Yilmaz, Y.; Gurel, S.; Nak, S.G.; Erdinc, S.; Gulten, M.
    Baseline and salt-stimulated paraoxonase and arylesterase activities in patients with chronic liver disease: Relation with disease severity (2009), Intern. Med. J., 39, 243-248.
    View publication on PubMed

Application

Application Comment Organism
medicine baseline and stimulated ARE activity is significantly lower in patients with chronic liver disease than in controls, serum ARE activity can be a suitable biomarker for the evaluation of the presence and severity of chronic liver damage Homo sapiens
medicine serum ARE activity may be a suitable biomarker for identifying the presence and severity of chronic liver injury Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl acetate + H2O
-
Homo sapiens 4-nitrophenol + acetate
-
?
phenyl acetate + H2O
-
Homo sapiens phenol + acetate
-
?

Synonyms

Synonyms Comment Organism
ARE
-
Homo sapiens
arylesterase
-
Homo sapiens

General Information

General Information Comment Organism
physiological function baseline and stimulated paraoxonase (PON1) and ARE activities are significantly lower in patients with chronic liver disease (by 32%) than in controls. ARE activity is significantly decreased (by 55%) in liver cirrhosis patients. ARE activity is significantly lower (by 35%) in cirrhotic patients compared with the chronic hepatitis group. ARE/high-density lipoprotein and the ARE/apolipoprotein A1 ratios are significantly reduced in patients with chronic hepatitis compared with controls. Similarly, the ARE/high-density lipoprotein and the ARE/apolipoprotein A1 ratios are significantly lower in patients with cirrhosis than in controls Homo sapiens