Any feedback?
Literature summary for 3.1.1.2 extracted from
- Paraoxonase (PON1) polymorphism and activity as the determinants of sensitivity to organophosphates in human subjects (2007), Chem. Biol. Interact., 168, 184-192.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene PON1, genotyping, naturally occuring polymorphisms in the gene coding and the promoter regions affect the activity and the enzyme level | Homo sapiens |
| genotyping of naturally occuring polymorphisms, allele frequency determination | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| L55M | naturally occuring polymorphism, allele frequency in relation to exposure of individuals to organophosphates, overview | Homo sapiens |
| L55M | naturally occuring polymorphism, the paraoxonase activity of the enzyme is altered | Homo sapiens |
| Q192R | naturally occuring polymorphism, allele frequency in relation to exposure of individuals to organophosphates, overview | Homo sapiens |
| Q192R | naturally occuring polymorphism, the paraoxonase activity of the enzyme is altered | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| organophosphorous compounds | inhibit the enzyme of all genotypes slightly after in vivo exposure | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | required | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | polymorphisms allele frequency in relation to exposure of individuals to organophosphates, overview | ? | - |
? | |
| additional information | Homo sapiens | the enzyme is important in the mechanism of organophosphorous toxicity | ? | - |
? | |
| phenylacetate + H2O | Homo sapiens | - |
phenol + acetate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Homo sapiens | P27169 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood serum | - |
Homo sapiens | - |
| serum | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
activity of different genotypes after exposure to high or low organophosphorous compound levels, overview | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | polymorphisms allele frequency in relation to exposure of individuals to organophosphates, overview | Homo sapiens | ? | - |
? | |
| additional information | the enzyme is important in the mechanism of organophosphorous toxicity | Homo sapiens | ? | - |
? | |
| phenylacetate + H2O | - |
Homo sapiens | phenol + acetate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| paraoxonase | - |
Homo sapiens |
| PON1 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
