Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
duodenum | low expression | Homo sapiens | - |
ileum | low expression | Homo sapiens | - |
jejunum | low expression | Homo sapiens | - |
kidney | low expression | Homo sapiens | - |
liver | high expression | Homo sapiens | - |
lung | low expression | Homo sapiens | - |
small intestine | high expression | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CPT-11 + H2O | CPT-11 is also named irinotecan, i.e. 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin. Human intestine carboxylesterase demonstrates the most efficient kinetic parameters for CPT-11 hydrolysis to the active metabolite SN-38 | Homo sapiens | SN-38 + 1,4'-bipiperidine-1'-carboxylic acid + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CE1 | hepatic carboxylesterase | Homo sapiens |
CES1 | hepatic carboxylesterase | Homo sapiens |
hiCE | intestinal carboxylaesterase | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | hepatic carboxylesterase CE1 plays a significant role in CPT-11 hydrolysis even though it is up to 100fold less efficient at drug activation than intestinal carboxylesterase. The drug activation in the intestine and kidney are likely major contributors to SN-38 production in vivo | Homo sapiens |