Application | Comment | Organism |
---|---|---|
drug development | the major human hepatic hydrolase, carboxylesterase 1 serves as a target of metabolic inhibition by a variety of medications | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
11-piperazin-1-yl-dibenzo[b,f][1,4]thiazepine | - |
Homo sapiens | |
aripiprazole | - |
Homo sapiens | |
atomoxetine | - |
Homo sapiens | |
clozapine | - |
Homo sapiens | |
fluoxetine | - |
Homo sapiens | |
haloperidol | - |
Homo sapiens | |
imipramine | - |
Homo sapiens | |
additional information | no inhibition by clonidine, phenylephrine, risperidone, and paliperidone. Quantitative structure-activity relationship of potential inhibitors, molecular modeling of, overview. Drug-drug interactions with substrate methylphenidate, overview | Homo sapiens | |
n-desmethylclozapine | - |
Homo sapiens | |
olanzapine | - |
Homo sapiens | |
perphenazine | - |
Homo sapiens | |
quetiapine | - |
Homo sapiens | |
thioridazine | - |
Homo sapiens | |
ziprasidone | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl acetate + H2O | - |
Homo sapiens | 4-nitrophenol + acetate | - |
? | |
D-methylphenidate + H2O | - |
Homo sapiens | methanol + phenyl(piperidin-2-yl)acetate | - |
? | |
DL-methylphenidate + H2O | - |
Homo sapiens | methanol + phenyl(piperidin-2-yl)acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
carboxylesterase 1 | - |
Homo sapiens |
CES1 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00338 | - |
versus substrate 4-nitrophenyl acetate | Homo sapiens | olanzapine | |
0.00359 | - |
versus substrate 4-nitrophenyl acetate | Homo sapiens | haloperidol | |
0.00372 | - |
versus substrate 4-nitrophenyl acetate | Homo sapiens | imipramine | |
0.00399 | - |
versus substrate 4-nitrophenyl acetate | Homo sapiens | n-desmethylclozapine | |
0.00402 | - |
versus substrate 4-nitrophenyl acetate | Homo sapiens | 11-piperazin-1-yl-dibenzo[b,f][1,4]thiazepine | |
0.00407 | - |
versus substrate 4-nitrophenyl acetate | Homo sapiens | atomoxetine | |
0.00409 | - |
versus substrate 4-nitrophenyl acetate | Homo sapiens | clozapine | |
0.00413 | - |
versus substrate 4-nitrophenyl acetate | Homo sapiens | ziprasidone | |
0.00415 | - |
versus substrate 4-nitrophenyl acetate | Homo sapiens | quetiapine | |
0.00486 | - |
versus substrate 4-nitrophenyl acetate | Homo sapiens | perphenazine | |
0.00515 | - |
versus substrate 4-nitrophenyl acetate | Homo sapiens | thioridazine | |
0.00521 | - |
versus substrate 4-nitrophenyl acetate | Homo sapiens | fluoxetine | |
0.00524 | - |
versus substrate 4-nitrophenyl acetate | Homo sapiens | aripiprazole | |
0.0583 | - |
versus substrate methylphenidate | Homo sapiens | thioridazine | |
0.0589 | - |
versus substrate methylphenidate | Homo sapiens | fluoxetine | |
0.0617 | - |
versus substrate methylphenidate | Homo sapiens | aripiprazole | |
0.065 | - |
versus substrate methylphenidate | Homo sapiens | perphenazine |
General Information | Comment | Organism |
---|---|---|
physiological function | CES1 plays a role in the metabolism and detoxification of many compounds | Homo sapiens |