Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,1,1-trifluoro-3-(hexyloxy)propane-2,2-diol | - |
Homo sapiens | |
1,1,1-trifluoro-3-(hexyloxy)propane-2,2-diol | - |
Oryctolagus cuniculus | |
1,1,1-trifluoro-3-(hexylsulfanyl)propan-2-one | - |
Homo sapiens | |
1,1,1-trifluoro-3-(hexylsulfanyl)propan-2-one | - |
Oryctolagus cuniculus | |
1,1,1-trifluoro-3-(hexylsulfinyl)propane-2,2-diol | - |
Homo sapiens | |
1,1,1-trifluoro-3-(hexylsulfinyl)propane-2,2-diol | - |
Oryctolagus cuniculus | |
1,1,1-trifluoro-3-(hexylsulfonyl)propane-2,2-diol | - |
Homo sapiens | |
1,1,1-trifluoro-3-(hexylsulfonyl)propane-2,2-diol | - |
Oryctolagus cuniculus | |
1,1,1-trifluoro-3-(octylsulfanyl)propan-2-one | - |
Homo sapiens | |
1,1,1-trifluoro-3-(octylsulfanyl)propan-2-one | - |
Oryctolagus cuniculus | |
1,1,1-trifluoro-3-(octylsulfinyl)propane-2,2-diol | - |
Homo sapiens | |
1,1,1-trifluoro-3-(octylsulfinyl)propane-2,2-diol | - |
Oryctolagus cuniculus | |
1,1,1-trifluoro-3-(octylsulfonyl)propane-2,2-diol | - |
Homo sapiens | |
1,1,1-trifluoro-3-(octylsulfonyl)propane-2,2-diol | - |
Oryctolagus cuniculus | |
1,1,1-trifluoro-3-[(2-phenylethyl)sulfanyl]propan-2-one | - |
Homo sapiens | |
1,1,1-trifluoro-3-[(2-phenylethyl)sulfanyl]propan-2-one | - |
Oryctolagus cuniculus | |
1,1,1-trifluoro-3-[(2-phenylethyl)sulfonyl]propane-2,2-diol | - |
Homo sapiens | |
1,1,1-trifluoro-3-[(2-phenylethyl)sulfonyl]propane-2,2-diol | - |
Oryctolagus cuniculus | |
1,1,1-trifluorododecan-2-one | - |
Homo sapiens | |
1,1,1-trifluorododecan-2-one | - |
Oryctolagus cuniculus | |
1,2-bis(2-chlorophenyl)ethane-1,2-dione | - |
Homo sapiens | |
1,2-bis(2-chlorophenyl)ethane-1,2-dione | - |
Oryctolagus cuniculus | |
1,2-bis(3,4,5-trifluorophenyl)ethane-1,2-dione | - |
Homo sapiens | |
1,2-bis(3,4,5-trifluorophenyl)ethane-1,2-dione | - |
Oryctolagus cuniculus | |
1,2-bis(3,5-difluorophenyl)ethane-1,2-dione | - |
Homo sapiens | |
1,2-bis(3,5-difluorophenyl)ethane-1,2-dione | - |
Oryctolagus cuniculus | |
1,2-bis(3-methoxyphenyl)ethane-1,2-dione | - |
Homo sapiens | |
1,2-bis(3-methoxyphenyl)ethane-1,2-dione | - |
Oryctolagus cuniculus | |
1,2-bis(3-nitrophenyl)ethane-1,2-dione | - |
Homo sapiens | |
1,2-bis(3-nitrophenyl)ethane-1,2-dione | - |
Oryctolagus cuniculus | |
1,2-bis(4-bromo-2-methoxyphenyl)ethane-1,2-dione | - |
Homo sapiens | |
1,2-bis(4-bromo-2-methoxyphenyl)ethane-1,2-dione | - |
Oryctolagus cuniculus | |
1,2-bis(4-bromo-3-nitrophenyl)ethane-1,2-dione | - |
Homo sapiens | |
1,2-bis(4-bromo-3-nitrophenyl)ethane-1,2-dione | - |
Oryctolagus cuniculus | |
1,2-bis(4-bromothiophen-2-yl)ethane-1,2-dione | - |
Homo sapiens | |
1,2-bis(4-bromothiophen-2-yl)ethane-1,2-dione | - |
Oryctolagus cuniculus | |
1,2-bis(4-chlorophenyl)ethane-1,2-dione | - |
Homo sapiens | |
1,2-bis(4-chlorophenyl)ethane-1,2-dione | - |
Oryctolagus cuniculus | |
1,2-bis(4-fluorophenyl)ethane-1,2-dione | - |
Homo sapiens | |
1,2-bis(4-fluorophenyl)ethane-1,2-dione | - |
Oryctolagus cuniculus | |
1,2-bis(4-methoxyphenyl)ethane-1,2-dione | - |
Homo sapiens | |
1,2-bis(4-methoxyphenyl)ethane-1,2-dione | - |
Oryctolagus cuniculus | |
1,2-bis(4-methylphenyl)ethane-1,2-dione | - |
Homo sapiens | |
1,2-bis(4-methylphenyl)ethane-1,2-dione | - |
Oryctolagus cuniculus | |
1,2-bis(5-bromothiophen-2-yl)ethane-1,2-dione | - |
Homo sapiens | |
1,2-bis(5-bromothiophen-2-yl)ethane-1,2-dione | - |
Oryctolagus cuniculus | |
1,2-di(furan-2-yl)ethane-1,2-dione | - |
Homo sapiens | |
1,2-di(furan-2-yl)ethane-1,2-dione | - |
Oryctolagus cuniculus | |
1,2-di(naphthalen-2-yl)ethane-1,2-dione | - |
Homo sapiens | |
1,2-di(naphthalen-2-yl)ethane-1,2-dione | - |
Oryctolagus cuniculus | |
1,2-di(pyridin-2-yl)ethane-1,2-dione | - |
Homo sapiens | |
1,2-di(pyridin-2-yl)ethane-1,2-dione | - |
Oryctolagus cuniculus | |
1,2-di(thiophen-2-yl)ethane-1,2-dione | - |
Homo sapiens | |
1,2-di(thiophen-2-yl)ethane-1,2-dione | - |
Oryctolagus cuniculus | |
1,2-di(thiophen-3-yl)ethane-1,2-dione | - |
Homo sapiens | |
1,2-di(thiophen-3-yl)ethane-1,2-dione | - |
Oryctolagus cuniculus | |
1,2-diphenylethane-1,2-dione | - |
Homo sapiens | |
1,2-diphenylethane-1,2-dione | - |
Oryctolagus cuniculus | |
1-(2,4-dinitrophenyl)-2-phenylethane-1,2-dione | - |
Homo sapiens | |
1-(2,4-dinitrophenyl)-2-phenylethane-1,2-dione | - |
Oryctolagus cuniculus | |
1-(2-chlorophenyl)-2-(3,4-dimethoxyphenyl)ethane-1,2-dione | - |
Homo sapiens | |
1-(2-chlorophenyl)-2-(3,4-dimethoxyphenyl)ethane-1,2-dione | - |
Oryctolagus cuniculus | |
1-(3,4-dimethylphenyl)-2-phenylethane-1,2-dione | - |
Homo sapiens | |
1-(3,4-dimethylphenyl)-2-phenylethane-1,2-dione | - |
Oryctolagus cuniculus | |
1-(4-chlorophenyl)-2-(4-methylphenyl)ethane-1,2-dione | - |
Homo sapiens | |
1-(4-chlorophenyl)-2-(4-methylphenyl)ethane-1,2-dione | - |
Oryctolagus cuniculus | |
1-(4-chlorophenyl)-2-phenylethane-1,2-dione | - |
Homo sapiens | |
1-(4-chlorophenyl)-2-phenylethane-1,2-dione | - |
Oryctolagus cuniculus | |
1-(4-methoxyphenyl)-2-phenylethane-1,2-dione | - |
Homo sapiens | |
1-(4-methoxyphenyl)-2-phenylethane-1,2-dione | - |
Oryctolagus cuniculus | |
1-(4-methyl-3-nitrophenyl)-2-phenylethane-1,2-dione | - |
Homo sapiens | |
1-(4-methyl-3-nitrophenyl)-2-phenylethane-1,2-dione | - |
Oryctolagus cuniculus | |
1-(4-methylphenyl)-2-phenylethane-1,2-dione | - |
Homo sapiens | |
1-(4-methylphenyl)-2-phenylethane-1,2-dione | - |
Oryctolagus cuniculus | |
1-(4-nitrophenyl)-2-phenylethane-1,2-dione | - |
Homo sapiens | |
1-(4-nitrophenyl)-2-phenylethane-1,2-dione | - |
Oryctolagus cuniculus | |
1-(pentachlorophenyl)-2-(pentafluorophenyl)ethane-1,2-dione | - |
Homo sapiens | |
1-(pentachlorophenyl)-2-(pentafluorophenyl)ethane-1,2-dione | - |
Oryctolagus cuniculus | |
1-[4-(bromomethyl)phenyl]-2-phenylethane-1,2-dione | - |
Homo sapiens | |
1-[4-(bromomethyl)phenyl]-2-phenylethane-1,2-dione | - |
Oryctolagus cuniculus | |
1-[4-[oxo(phenyl)acetyl]phenyl]-2-phenylethane-1,2-dione | - |
Homo sapiens | |
1-[4-[oxo(phenyl)acetyl]phenyl]-2-phenylethane-1,2-dione | - |
Oryctolagus cuniculus | |
3-(butylsulfanyl)-1,1,1-trifluoropropan-2-one | - |
Homo sapiens | |
3-(butylsulfanyl)-1,1,1-trifluoropropan-2-one | - |
Oryctolagus cuniculus | |
3-(decylsulfanyl)-1,1,1-trifluoropropan-2-one | - |
Homo sapiens | |
3-(decylsulfanyl)-1,1,1-trifluoropropan-2-one | - |
Oryctolagus cuniculus | |
3-(decylsulfinyl)-1,1,1-trifluoropropane-2,2-diol | - |
Homo sapiens | |
3-(decylsulfinyl)-1,1,1-trifluoropropane-2,2-diol | - |
Oryctolagus cuniculus | |
3-(decylsulfonyl)-1,1,1-trifluoropropane-2,2-diol | - |
Homo sapiens | |
3-(decylsulfonyl)-1,1,1-trifluoropropane-2,2-diol | - |
Oryctolagus cuniculus | |
3-(dodecylsulfanyl)-1,1,1-trifluoropropan-2-one | - |
Homo sapiens | |
3-(dodecylsulfanyl)-1,1,1-trifluoropropan-2-one | - |
Oryctolagus cuniculus | |
3-(dodecylsulfinyl)-1,1,1-trifluoropropane-2,2-diol | - |
Homo sapiens | |
3-(dodecylsulfinyl)-1,1,1-trifluoropropane-2,2-diol | - |
Oryctolagus cuniculus | |
3-(dodecylsulfonyl)-1,1,1-trifluoropropane-2,2-diol | - |
Homo sapiens | |
3-(dodecylsulfonyl)-1,1,1-trifluoropropane-2,2-diol | - |
Oryctolagus cuniculus | |
4-[oxo(phenyl)acetyl]benzoic acid | - |
Homo sapiens | |
4-[oxo(phenyl)acetyl]benzoic acid | - |
Oryctolagus cuniculus | |
benzil | - |
Homo sapiens | |
benzil | - |
Oryctolagus cuniculus | |
additional information | several different scaffolds capable of inhibiting carboxylesterases are e.g. organophosphates, carbamates, trifluoromethyl ketone-containing structures, and aromatic ethane-1,2-diones. Comparison of diverse benzil analogues and dione-based carboxylesterase and trifluoromethyl ketone inhibitors in carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis, overview | Homo sapiens | |
additional information | several different scaffolds capable of inhibiting carboxylesterases are e.g. organophosphates, carbamates, trifluoromethyl ketone-containing structures, and aromatic ethane-1,2-diones. Comparison of diverse benzil analogues and dione-based and trifluoromethyl ketone carboxylesterase inhibitors in carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis, overview | Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
camptothecin-11 + H2O | Homo sapiens | i.e. CPT-11, an anti-tumor agent | ? | - |
? | |
camptothecin-11 + H2O | Oryctolagus cuniculus | i.e. CPT-11, an anti-tumor agent | ? | - |
? | |
clopidogrel + H2O | Homo sapiens | an anti-thrombogenic agent | (2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanoic acid + methanol | - |
? | |
clopidogrel + H2O | Oryctolagus cuniculus | an anti-thrombogenic agent | (2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanoic acid + methanol | - |
? | |
additional information | Homo sapiens | carboxylesterases are enzymes that hydrolyze a broad suite of endogenous and exogenous ester-containing compounds to the corresponding alcohol and carboxylic acid | ? | - |
? | |
additional information | Oryctolagus cuniculus | carboxylesterases are enzymes that hydrolyze a broad suite of endogenous and exogenous ester-containing compounds to the corresponding alcohol and carboxylic acid | ? | - |
? | |
oseltamivir + H2O | Homo sapiens | an anti-viral drug | ? | - |
? | |
oseltamivir + H2O | Oryctolagus cuniculus | an anti-viral drug | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | recombinant enzyme | Oryctolagus cuniculus | - |
intestine | intestinal CE | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
camptothecin-11 + H2O | i.e. CPT-11, an anti-tumor agent | Homo sapiens | ? | - |
? | |
camptothecin-11 + H2O | i.e. CPT-11, an anti-tumor agent | Oryctolagus cuniculus | ? | - |
? | |
camptothecin-11 + H2O | i.e. CPT-11 | Homo sapiens | ? | - |
? | |
camptothecin-11 + H2O | i.e. CPT-11 | Oryctolagus cuniculus | ? | - |
? | |
clopidogrel + H2O | - |
Homo sapiens | (2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanoic acid + methanol | - |
? | |
clopidogrel + H2O | - |
Oryctolagus cuniculus | (2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanoic acid + methanol | - |
? | |
clopidogrel + H2O | an anti-thrombogenic agent | Homo sapiens | (2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanoic acid + methanol | - |
? | |
clopidogrel + H2O | an anti-thrombogenic agent | Oryctolagus cuniculus | (2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanoic acid + methanol | - |
? | |
additional information | carboxylesterases are enzymes that hydrolyze a broad suite of endogenous and exogenous ester-containing compounds to the corresponding alcohol and carboxylic acid | Homo sapiens | ? | - |
? | |
additional information | carboxylesterases are enzymes that hydrolyze a broad suite of endogenous and exogenous ester-containing compounds to the corresponding alcohol and carboxylic acid | Oryctolagus cuniculus | ? | - |
? | |
oseltamivir + H2O | - |
Homo sapiens | ? | - |
? | |
oseltamivir + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
oseltamivir + H2O | an anti-viral drug | Homo sapiens | ? | - |
? | |
oseltamivir + H2O | an anti-viral drug | Oryctolagus cuniculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
carboxylesterase 1 | - |
Homo sapiens |
CE1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | carboxylesterases are involved in lipid homeostasis, including cholesterol metabolism and transport with a proposed role in the development of atherosclerosis | Homo sapiens |
physiological function | carboxylesterases are involved in lipid homeostasis, including cholesterol metabolism and transport with a proposed role in the development of atherosclerosis | Oryctolagus cuniculus |