Cloned (Comment) | Organism |
---|---|
expressed in Flp-In-293 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
G143E | the mutant does not hydrolyze trandolapril | Homo sapiens |
additional information | mutant enzyme Asp260fs is an essentially dysfunctional enzyme with regard to the hydrolysis of trandolapril | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.639 | - |
trandolapril | wild type enzyme, in PBS containing 10 mM HEPES, pH 7.4, at 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
additional information | isozyme CES1 is not expressed in human intestinal microsomes | Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestine | isozyme CES2 | Homo sapiens | - |
liver | isozyme CES1 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trandolapril + H2O | trandolapril is a CES1 selective substrate while CES2 exerts little to no catalytic activity towards this compound | Homo sapiens | trandolaprilat + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CES1 | isozyme | Homo sapiens |
CES2 | isozyme | Homo sapiens |