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Literature summary for 3.1.1.1 extracted from

  • Fleming, C.D.; Edwards, C.C.; Kirby, S.D.; Maxwell, D.M.; Potter, P.M.; Cerasoli, D.M.; Redinbo, M.R.
    Crystal structures of human carboxylesterase 1 in covalent complexes with the chemical warfare agents soman and tabun (2007), Biochemistry, 46, 5063-5071.
    View publication on PubMedView publication on EuropePMC
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Crystallization (Commentary)

Crystallization (Comment) Organism
covalent acyl-enzyme intermediate complexes of isoform hCE1 with inhibitors soman and tabun. Enzyme binds stereoselectively, (S)-stereoisomer of soman is preferred 10000fold over the (R)-isomer. Comparison with similar complexes of acetylcholinesterase Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
soman enzyme binds stereoselectively, (S)-stereoisomer of soman is preferred 10000fold over the (R)-isomer Homo sapiens
Tabun
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P23141 isoform hCE1
-