Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-chloro-3,4-dimethoxybenzil | blocks hydrolysis of trans-permethrin by isoform hCE2 36 times more efficiently than hCE1 | Homo sapiens | |
2-chloro-3,4-dimethoxybenzil | blocks hydrolysis of trans-permethrin by isoform hCE2 36 times more efficiently than hCE1 | Oryctolagus cuniculus | |
2-chloro-3,4-dimethoxybenzil | blocks hydrolysis of trans-permethrin by isoform hCE2 36 times more efficiently than hCE1 | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00672 | - |
bioresmethrin | isoform hCE1, pH 7.4, 37°C | Homo sapiens | |
0.00757 | - |
(1RS)-trans-permethrin | isoform hCE2, pH 7.4, 37°C | Homo sapiens | |
0.0086 | - |
(1RS)-cis-permethrin | isoform hCE2, pH 7.4, 37°C | Homo sapiens | |
0.0098 | - |
(1RS)-trans-permethrin | isoform hCE1, pH 7.4, 37°C | Homo sapiens | |
0.0238 | - |
(1RS)-cis-permethrin | isoform hCE1, pH 7.4, 37°C | Homo sapiens | |
1.93 | - |
(1RS)-cis-permethrin | hydrolase A, pH 7.4, 37°C | Rattus norvegicus | |
1.96 | - |
(1RS)-trans-permethrin | pH 7.4, 37°C | Oryctolagus cuniculus | |
4.96 | - |
(1RS)-cis-permethrin | hydrolase B, pH 7.4, 37°C | Rattus norvegicus | |
6.74 | - |
(1RS)-trans-permethrin | hydrolase A, pH 7.4, 37°C | Rattus norvegicus | |
9.8 | - |
(1RS)-trans-permethrin | hydrolase B, pH 7.4, 37°C | Rattus norvegicus | |
16.7 | - |
(1RS)-cis-permethrin | pH 7.4, 37°C | Oryctolagus cuniculus | |
25.75 | - |
bioresmethrin | pH 7.4, 37°C | Oryctolagus cuniculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isoforms hCE1 and hCE2 | - |
Oryctolagus cuniculus | - |
- |
- |
Rattus norvegicus | - |
hydrolases A and B | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
19.05 | - |
isoform hCE2, substrate 4-nitrophenyl acetate, pH 7.4, 37°C | Homo sapiens |
36.14 | - |
isoform hCE1, substrate 4-nitrophenyl acetate, pH 7.4, 37°C | Homo sapiens |
86.41 | - |
substrate 4-nitrophenyl acetate, pH 7.4, 37°C | Oryctolagus cuniculus |
90.1 | - |
isoform hCE2, substrate 4-nitrophenyl valerate, pH 7.4, 37°C | Homo sapiens |
113.2 | - |
isoform hCE1, substrate 4-nitrophenyl valerate, pH 7.4, 37°C | Homo sapiens |
126 | - |
substrate 4-nitrophenyl valerate, pH 7.4, 37°C | Oryctolagus cuniculus |
293.1 | - |
isoform hCE1, substrate 4-nitrophenyl butanoate, pH 7.4, 37°C | Homo sapiens |
315.2 | - |
isoform hCE2, substrate 4-nitrophenyl butanoate, pH 7.4, 37°C | Homo sapiens |
374 | - |
substrate 4-nitrophenyl butanoate, pH 7.4, 37°C | Oryctolagus cuniculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(1R)-bioresmethrin + H2O | - |
Oryctolagus cuniculus | ? | - |
? | |
(1R)-bioresmethrin + H2O | substrate for isoform hCE1, not for hCE2 | Homo sapiens | ? | - |
? | |
(1RS)-cis-permethrin + H2O | - |
Rattus norvegicus | cis-dichlorochrysamthemic acid + 3-phenoxybenzyl alcohol | - |
? | |
(1RS)-cis-permethrin + H2O | - |
Oryctolagus cuniculus | cis-dichlorochrysamthemic acid + 3-phenoxybenzyl alcohol | - |
? | |
(1RS)-cis-permethrin + H2O | isoforms hCE1 and hCE2 hydrolyze trans-permethrin 8- and 28fold more efficiently than cis-permethrin, resp. | Homo sapiens | cis-dichlorochrysamthemic acid + 3-phenoxybenzyl alcohol | - |
? | |
(1RS)-trans-permethrin + H2O | - |
Rattus norvegicus | trans-dichlorochrysamthemic acid + 3-phenoxybenzyl alcohol | - |
? | |
(1RS)-trans-permethrin + H2O | - |
Oryctolagus cuniculus | trans-dichlorochrysamthemic acid + 3-phenoxybenzyl alcohol | - |
? | |
(1RS)-trans-permethrin + H2O | isoforms hCE1 and hCE2 hydrolyze trans-permethrin 8- and 28fold more efficiently than cis-permethrin, resp. | Homo sapiens | trans-dichlorochrysamthemic acid + 3-phenoxybenzyl alcohol | - |
? | |
4-nitrophenyl acetate + H2O | - |
Homo sapiens | 4-nitrophenol + acetate | - |
? | |
4-nitrophenyl acetate + H2O | - |
Oryctolagus cuniculus | 4-nitrophenol + acetate | - |
? | |
4-nitrophenyl butanoate + H2O | - |
Homo sapiens | 4-nitrophenol + butanoate | - |
? | |
4-nitrophenyl butanoate + H2O | - |
Oryctolagus cuniculus | 4-nitrophenol + butanoate | - |
? | |
4-nitrophenyl valerate + H2O | - |
Homo sapiens | 4-nitrophenol + valerate | - |
? | |
4-nitrophenyl valerate + H2O | - |
Oryctolagus cuniculus | 4-nitrophenol + valerate | - |
? | |
bioresmethrin + H2O | - |
Homo sapiens | ? | - |
? | |
bioresmethrin + H2O | - |
Oryctolagus cuniculus | ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0008 | - |
(1RS)-trans-permethrin | isoform hCE2, pH 7.4, 37°C | Homo sapiens | |
0.0028 | - |
(1RS)-trans-permethrin | isoform hCE1, pH 7.4, 37°C | Homo sapiens | |
0.004 | - |
(1RS)-cis-permethrin | hydrolase A, pH 7.4, 37°C | Rattus norvegicus | |
0.0053 | - |
(1RS)-cis-permethrin | hydrolase B, pH 7.4, 37°C | Rattus norvegicus | |
0.016 | - |
(1RS)-trans-permethrin | pH 7.4, 37°C | Oryctolagus cuniculus | |
0.025 | - |
(1RS)-trans-permethrin | hydrolase B, pH 7.4, 37°C | Rattus norvegicus | |
0.028 | - |
(1RS)-cis-permethrin | isoform hCE2, pH 7.4, 37°C | Homo sapiens | |
0.034 | - |
bioresmethrin | isoform hCE1, pH 7.4, 37°C | Homo sapiens | |
0.036 | - |
(1RS)-trans-permethrin | hydrolase A, pH 7.4, 37°C | Rattus norvegicus | |
0.05 | - |
(1RS)-cis-permethrin | pH 7.4, 37°C | Oryctolagus cuniculus | |
0.056 | - |
(1RS)-cis-permethrin | isoform hCE1, pH 7.4, 37°C | Homo sapiens | |
0.11 | - |
bioresmethrin | pH 7.4, 37°C | Oryctolagus cuniculus |