KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.08 | - |
L-phenylalanine butyl ester | pH 7.4, 37°C | Sus scrofa | |
0.14 | - |
4-nitrophenyl butyrate | pH 7.4, 37°C | Sus scrofa | |
0.17 | - |
5'-L-phenylalanyl-gemcitabine | pH 7.4, 37°C | Sus scrofa | |
0.22 | - |
5'-D-phenylalanyl-gemcitabine | pH 7.4, 37°C | Sus scrofa | |
0.4 | - |
N-acetyl L-phenylalanine ethyl ester | pH 7.4, 37°C | Sus scrofa | |
0.46 | - |
5'-L-phenylalanine-floxuridine | pH 7.4, 37°C | Sus scrofa | |
0.51 | - |
3'-L-phenylalanyl-gemcitabine | pH 7.4, 37°C | Sus scrofa | |
0.52 | - |
4-nitrophenyl acetate | pH 7.4, 37°C | Sus scrofa | |
0.63 | - |
5'-cinnamic acid-floxuridine | pH 7.4, 37°C | Sus scrofa | |
0.85 | - |
5'-L-isoleucyl-gemcitabine | pH 7.4, 37°C | Sus scrofa | |
0.9 | - |
5'-D-phenylalanyl-BDCRB | pH 7.4, 37°C | Sus scrofa | |
0.9 | - |
3'-L-valyl-gemcitabine | pH 7.4, 37°C | Sus scrofa | |
0.91 | - |
5'-L-phenylalanyl-BDCRB | pH 7.4, 37°C | Sus scrofa | |
0.94 | - |
3'-L-isoleucyl-gemcitabine | pH 7.4, 37°C | Sus scrofa | |
0.96 | - |
5'-L-valyl-gemcitabine | pH 7.4, 37°C | Sus scrofa | |
0.97 | - |
3'-D-phenylalanyl-gemcitabine | pH 7.4, 37°C | Sus scrofa | |
1.16 | - |
5'-D-valyl-gemcitabine | pH 7.4, 37°C | Sus scrofa | |
1.18 | - |
L-phenylalanine ethyl ester | pH 7.4, 37°C | Sus scrofa | |
1.43 | - |
3'-D-valyl-gemcitabine | pH 7.4, 37°C | Sus scrofa | |
4.21 | - |
irinotecan | pH 7.4, 37°C | Sus scrofa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
isoenzyme carboxylase 1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-D-phenylalanyl-gemcitabine + H2O | - |
Sus scrofa | D-phenylalanine + gemcitabine | - |
? | |
3'-D-valyl-gemcitabine + H2O | - |
Sus scrofa | D-valine + gemcitabine | - |
? | |
3'-L-isoleucyl-gemcitabine + H2O | - |
Sus scrofa | L-isoleucine + gemcitabine | - |
? | |
3'-L-phenylalanyl-gemcitabine + H2O | - |
Sus scrofa | L-phenylalanine + gemcitabine | - |
? | |
3'-L-valyl-gemcitabine + H2O | - |
Sus scrofa | L-valine + gemcitabine | - |
? | |
4-nitrophenyl acetate + H2O | - |
Sus scrofa | 4-nitrophenol + acetate | - |
? | |
4-nitrophenyl butanoate + H2O | - |
Sus scrofa | 4-nitrophenol + butanoate | - |
? | |
5'-D-phenylalanyl-2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole + H2O | - |
Sus scrofa | D-phenylalanine + 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole | - |
? | |
5'-D-phenylalanyl-gemcitabine + H2O | - |
Sus scrofa | D-phenylalanine + gemcitabine | - |
? | |
5'-D-valyl-gemcitabine + H2O | - |
Sus scrofa | D-valine + gemcitabine | - |
? | |
5'-L-isoleucyl-gemcitabine + H2O | - |
Sus scrofa | L-isoleucine + gemcitabine | - |
? | |
5'-L-phenylalanyl-2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole + H2O | - |
Sus scrofa | L-phenylalanine + 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole | - |
? | |
5'-L-phenylalanyl-gemcitabine + H2O | - |
Sus scrofa | L-phenylalanine + gemcitabine | - |
? | |
5'-L-valyl-gemcitabine + H2O | - |
Sus scrofa | L-valine + gemcitabine | - |
? | |
5'-O-cinnamoyl-2'-deoxy-5-fluorouridine + H2O | - |
Sus scrofa | cinnamic acid + 2'-deoxy-5-fluorouridine | - |
? | |
5'-O-L-phenylalanyl-2'-deoxy-5-fluorouridine + H2O | - |
Sus scrofa | L-phenylalanine + 2'-deoxy-5-fluorouridine | - |
? | |
irinotecan + H2O | - |
Sus scrofa | ? | - |
? | |
L-phenylalanine butyl ester + H2O | - |
Sus scrofa | L-phenylalanine + butanol | - |
? | |
L-phenylalanine ethyl ester + H2O | - |
Sus scrofa | L-phenylalanine + ethanol | - |
? | |
additional information | enzyme shows high catalytic efficiency hydrolyzing prodrugs containing a phenylalanyl moiety, but is over 100fold less efficient with valyl or isoleucyl prodrugs | Sus scrofa | ? | - |
? | |
N-acetyl L-phenylalanine ethyl ester + H2O | - |
Sus scrofa | N-acetyl L-phenylalanine + ethanol | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.008 | - |
5'-D-valyl-gemcitabine | pH 7.4, 37°C | Sus scrofa | |
0.008 | - |
5'-L-valyl-gemcitabine | pH 7.4, 37°C | Sus scrofa | |
0.01 | - |
irinotecan | pH 7.4, 37°C | Sus scrofa | |
0.08 | - |
3'-L-isoleucyl-gemcitabine | pH 7.4, 37°C | Sus scrofa | |
0.08 | - |
L-phenylalanine butyl ester | pH 7.4, 37°C | Sus scrofa | |
0.11 | - |
3'-L-valyl-gemcitabine | pH 7.4, 37°C | Sus scrofa | |
0.33 | - |
5'-L-isoleucyl-gemcitabine | pH 7.4, 37°C | Sus scrofa | |
0.45 | - |
N-acetyl L-phenylalanine ethyl ester | pH 7.4, 37°C | Sus scrofa | |
0.55 | - |
5'-D-phenylalanyl-BDCRB | pH 7.4, 37°C | Sus scrofa | |
0.62 | - |
5'-L-phenylalanine-floxuridine | pH 7.4, 37°C | Sus scrofa | |
1.1 | - |
5'-L-phenylalanyl-gemcitabine | pH 7.4, 37°C | Sus scrofa | |
1.1 | - |
5'-D-phenylalanyl-gemcitabine | pH 7.4, 37°C | Sus scrofa | |
1.1 | - |
3'-D-valyl-gemcitabine | pH 7.4, 37°C | Sus scrofa | |
1.38 | - |
5'-cinnamic acid-floxuridine | pH 7.4, 37°C | Sus scrofa | |
6.1 | - |
3'-L-phenylalanyl-gemcitabine | pH 7.4, 37°C | Sus scrofa | |
8 | - |
5'-L-phenylalanyl-BDCRB | pH 7.4, 37°C | Sus scrofa | |
8.7 | - |
3'-D-phenylalanyl-gemcitabine | pH 7.4, 37°C | Sus scrofa | |
20 | - |
4-nitrophenyl acetate | pH 7.4, 37°C | Sus scrofa | |
27.4 | - |
4-nitrophenyl butyrate | pH 7.4, 37°C | Sus scrofa | |
63.6 | - |
L-phenylalanine ethyl ester | pH 7.4, 37°C | Sus scrofa |