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Literature summary for 3.1.1.1 extracted from
- Catalytic properties of an unspecific carboxylesterase (E1) from rat-liver microsomes (1973), Eur. J. Biochem., 36, 129-134.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0184 | - |
ethyl iodoacetate | - |
Rattus norvegicus |  |
| 0.0313 | - |
ethyl bromoacetate | - |
Rattus norvegicus | |
| 0.083 | - |
ethyl chloroacetate | - |
Rattus norvegicus | |
| 0.11 | - |
n-butyl n-butyrate | - |
Rattus norvegicus | |
| 0.125 | - |
4-nitrophenyl acetate | - |
Rattus norvegicus | |
| 0.132 | - |
procaine | - |
Rattus norvegicus | |
| 0.25 | - |
hostacaine | - |
Rattus norvegicus | |
| 0.263 | - |
4-nitrophenyl butyrate | - |
Rattus norvegicus | |
| 0.333 | - |
ethyl fluoroacetate | - |
Rattus norvegicus | |
| 1.22 | - |
Tyr ethyl ester | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-nitrophenyl acetate + H2O | - |
Rattus norvegicus | 4-nitrophenol + acetate | - |
? | |
| 4-nitrophenyl butyrate + H2O | - |
Rattus norvegicus | 4-nitrophenol + butyrate | - |
? | |
| ethyl bromoacetate + H2O | - |
Rattus norvegicus | ethanol + bromoacetate | - |
? | |
| ethyl chloroacetate + H2O | - |
Rattus norvegicus | ethanol + chloroacetate | - |
? | |
| ethyl fluoroacetate + H2O | - |
Rattus norvegicus | ethanol + fluoroacetate | - |
? | |
| ethyl iodoacetate + H2O | - |
Rattus norvegicus | ethanol + iodoacetate | - |
? | |
| hostacaine + H2O | - |
Rattus norvegicus | ? | - |
? | |
| L-Tyr ethyl ester + H2O | - |
Rattus norvegicus | L-Tyr + ethanol | - |
? | |
| additional information | - |
Rattus norvegicus | ? | - |
? | |
| n-butyl n-butyrate + H2O | - |
Rattus norvegicus | n-butanol + n-butyrate | - |
? | |
| procaine + H2O | - |
Rattus norvegicus | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 10 | hydrolysis of methyl butyrate, at optimal methyl butyrate concentrations, 0.01 M | Rattus norvegicus |
| 7.5 | - |
hydrolysis of methyl hutyrate, at high substrate concentrations, 0.5 M | Rattus norvegicus |
| 8 | 8.5 | hydrolysis of p-nitrophenyl acetate | Rattus norvegicus |
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