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Literature summary for 2.8.2.30 extracted from

  • Zhang, L.; Song, K.; Zhou, L.; Xie, Z.; Zhou, P.; Zhao, Y.; Han, Y.; Xu, X.; Li, P.
    Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3B1 (HS3ST3B1) promotes angiogenesis and proliferation by induction of VEGF in acute myeloid leukemia cells (2015), J. Cell. Biochem., 116, 1101-1112.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine Homo sapiens
-
adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y662
-
-

Source Tissue

Source Tissue Comment Organism Textmining
acute myeloid leukemia cell
-
Homo sapiens
-
U-937 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine
-
Homo sapiens adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
-
?

Synonyms

Synonyms Comment Organism
heparan sulfate D-glucosamine 3-O-sulfotransferase 3B1
-
Homo sapiens
HS3ST3B1
-
Homo sapiens

General Information

General Information Comment Organism
physiological function isoform HS3ST3B1 positively contributes to acute myeloid leukemia progression. The enzyme increases vascular endothelial growth factor expression and release by leukemia cells and promotes the activation of the Notch-1-Jagged-1, PI3K-AKT and ERK pathways Homo sapiens