Literature summary for 2.8.1.2 extracted from

Mikami, Y.; Shibuya, N.; Kimura, Y.; Nagahara, N.; Ogasawara, Y.; Kimura, H.
Thioredoxin and dihydrolipoic acid are required for 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfide (2011), Biochem. J., 439, 479-485.

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Protein Variants

Protein Variants	Comment	Organism
C247S	inactive	Mus musculus
R187G	inactive	Mus musculus
R196G	the mutant shows reduced H2S-producing activity	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
sulfite	H2S production by the enzyme is suppressed by sulfite	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Mus musculus	5739	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3-mercaptopyruvate + thiosulfate	-	Mus musculus	pyruvate + H2S	-	?
additional information	the enzyme produces hydrogen sulfide in the presence of both cysteine and 2-oxoglutarate. Thioredoxin and dihydrolipoic acid associate with 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfide. Other reducing substances, such as NADPH, NADH, GSH, cysteine and CoA, do not have any effect on the reaction	Mus musculus	?	-	?

Synonyms

Synonyms	Comment	Organism
3MST	-	Mus musculus

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Release 2023.1 (January 2023)