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Literature summary for 2.8.1.2 extracted from
- 3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain (2009), Antioxid. Redox Signal., 11, 703-714.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| transient transfection of human embryonic kidney HEK 293-F cells | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C247S | site-directed mutagenesis, transient transfection of human embryonic kidney HEK 293-F cells, mutant completely lose the activity to metabolize 3-mercaptopyruvate that is assessed by measuring its products either pyruvate or H2S, the levels of bound sulfane sulfur are not increased | Mus musculus |
| R187G | site-directed mutagenesis, transient transfection of human embryonic kidney HEK 293-F cells, mutant, which greatly lose the activity, decreases the levels of bound sulfane sulfur, but not statistically significant, no H2S production | Mus musculus |
| R196G | site-directed mutagenesis, transient transfection of human embryonic kidney HEK 293-F cells, mutant, which partially lose the activity, does not decrease the levels of bound sulfane sulfur, no H2S production | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-mercaptopyruvate + cyanide | Mus musculus | H2S is produced by 3-mercaptopyruvate sulfurtransferase with cysteine aminotransferase in the presence of cysteine and alpha-ketoglutarate, supporting the existence of 3-mercaptopyruvate which has not been identified. Mercaptopyruvate can be provided by the metabolism of cysteine and alpha-ketoglutarate by cysteine aminotransferase (CAT) | H2S + ? | a major source of H2S production in the brain is from the enzyme 3-mercaptopyruvate sulfurtransferase | ? |  |
| additional information | Mus musculus | 3-mercaptopyruvate sulfurtransferase produces bound sulfane sulfur | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q99J99 | expression in human embryonic kidney HEK 293-F cells | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-mercaptopyruvate + cyanide | H2S is produced by 3-mercaptopyruvate sulfurtransferase with cysteine aminotransferase in the presence of cysteine and alpha-ketoglutarate, supporting the existence of 3-mercaptopyruvate which has not been identified. Mercaptopyruvate can be provided by the metabolism of cysteine and alpha-ketoglutarate by cysteine aminotransferase (CAT) | Mus musculus | H2S + ? | a major source of H2S production in the brain is from the enzyme 3-mercaptopyruvate sulfurtransferase | ? | |
| additional information | 3-mercaptopyruvate sulfurtransferase produces bound sulfane sulfur | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3-mercaptopyruvate sulfurtransferase | - |
Mus musculus |
| 3MST | - |
Mus musculus |
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