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Literature summary for 2.8.1.2 extracted from

  • Porter, D.W.; Baskin, S.I.
    The effect of three alpha-keto acids on 3-mercaptopyruvate sulfurtransferase activity (1996), J. Biochem. Toxicol., 11, 45-50.
    View publication on PubMed
Search for more literature for 2.8.1.2

Inhibitors

Inhibitors Comment Organism Structure
alpha-Ketobutyrate uncompetitive inhibitor with respect to 3-mercaptopyruvate, 50% inhibition at 13.7 mM Bos taurus
alpha-ketoglutarate uncompetitive inhibitor with respect to 3-mercaptopyruvate, 50% inhibition at 9.5 mM Bos taurus
pyruvate uncompetitive inhibitor with respect to 3-mercaptopyruvate, 50% inhibition at 13.1 mM Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.08
-
 3-Mercaptopyruvate pH 8, 30°C Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32000
-
 SDS-PAGE Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-mercaptopyruvate + cyanide Bos taurus
-
 pyruvate + thiocyanate
-
 ?
additional information Bos taurus cyanide detoxification ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-mercaptopyruvate + cyanide
-
 Bos taurus pyruvate + thiocyanate
-
 ?
additional information cyanide detoxification Bos taurus ?
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
6.1
-
 alpha-ketoglutarate pH 8, 30°C Bos taurus
6.1
-
 alpha-Ketobutyrate pH 8, 30°C Bos taurus
6.4
-
 pyruvate pH 8, 30°C Bos taurus