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Literature summary for 2.7.9.3 extracted from

  • Lee, K.H.; Shim, M.S.; Kim, J.Y.; Jung, H.K.; Lee, E.; Carlson, B.A.; Xu, X.M.; Park, J.M.; Hatfield, D.L.; Park, T.; Lee, B.J.
    Drosophila selenophosphate synthetase 1 regulates vitamin B6 metabolism: prediction and confirmation (2011), BMC Genomics, 12, 426.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.9.3

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
SCHNEIDER-2 cell
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + selenide + H2O
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 Drosophila melanogaster AMP + selenophosphate + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
selenophosphate synthetase 1
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 Drosophila melanogaster
SPS 1
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 Drosophila melanogaster

General Information

General Information Comment Organism
malfunction vitamin B6 biosynthesis is significantly affected at the early stage at which megamitochondria are not formed (day 3) after isoform SPS1 knockdown. Genes related to defense and amino acid metabolism are affected at a later stage (day 5) following enzyme knockdown. Levels of pyridoxal phosphate, an active form of vitamin B6, are decreased by isoform SPS1 knockdown Drosophila melanogaster
metabolism isoform selenophosphate synthetase 1 regulates vitamin B6 metabolism Drosophila melanogaster