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Literature summary for 2.7.8.7 extracted from

  • Jiang, H.; Wang, Y.Y.; Ran, X.X.; Fan, W.M.; Jiang, X.H.; Guan, W.J.; Li, Y.Q.
    Improvement of natamycin production by engineering of phosphopantetheinyl transferases in Streptomyces chattanoogensis L10 (2013), Appl. Environ. Microbiol., 79, 3346-3354.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.8.7

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Streptomyces chattanoogensis

Organism

Organism UniProt Comment Textmining
Streptomyces chattanoogensis H9N836
-
-
Streptomyces chattanoogensis H9N839
-
-
Streptomyces chattanoogensis L10 H9N836
-
-
Streptomyces chattanoogensis L10 H9N839
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA agarose column chromatography Streptomyces chattanoogensis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CoA-[4'-phosphopantetheine] + apo-[acyl-carrier protein]
-
 Streptomyces chattanoogensis adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]
-
 ?
CoA-[4'-phosphopantetheine] + apo-[acyl-carrier protein]
-
 Streptomyces chattanoogensis L10 adenosine 3',5'-bisphosphate + holo-[acyl-carrier protein]
-
 ?
additional information the enzyme catalyzes the phosphopantetheinylation of acyl carrier proteins in both type I polyketide synthases and type II polyketide synthases Streptomyces chattanoogensis ?
-
 ?
additional information the enzyme catalyzes the phosphopantetheinylation of acyl carrier proteins in type II polyketide synthases and fatty acid synthases Streptomyces chattanoogensis ?
-
 ?
additional information the enzyme catalyzes the phosphopantetheinylation of acyl carrier proteins in both type I polyketide synthases and type II polyketide synthases Streptomyces chattanoogensis L10 ?
-
 ?
additional information the enzyme catalyzes the phosphopantetheinylation of acyl carrier proteins in type II polyketide synthases and fatty acid synthases Streptomyces chattanoogensis L10 ?
-
 ?

Synonyms

Synonyms Comment Organism
AcpS
-
 Streptomyces chattanoogensis
phosphopantetheinyl transferase
-
 Streptomyces chattanoogensis
PPT
-
 Streptomyces chattanoogensis
PPTase
-
 Streptomyces chattanoogensis

Cofactor

Cofactor Comment Organism Structure
4'-phosphopantetheine
-
 Streptomyces chattanoogensis

General Information

General Information Comment Organism
malfunction inactivation of the enzyme abolishes production of natamycin but not the spore pigment Streptomyces chattanoogensis
physiological function overexpression of the enzyme not only increases the natamycin production by about 40% but also accelerates productions of both natamycin and the spore pigment Streptomyces chattanoogensis