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Literature summary for 2.7.8.7 extracted from
- A dedicated phosphopantetheinyl transferase for the fredericamycin polyketide synthase from Streptomyces griseus (2006), J. Biol. Chem., 281, 29660-29668.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | enzyme inactivation mutant shows 93% reduction in fredericamycin synthesis | Streptomyces griseus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0058 | - |
apo-[fredericamycin H acyl-carrier protein] | pH 8.0, 37°C | Streptomyces griseus |  |
| 0.1 | - |
apo-[tetracenomycin M acyl-carrier protein] | pH 8.0, 37°C | Streptomyces griseus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 59807 | - |
x * 59807, calculated, x * 60000, SDS-PAGE | Streptomyces griseus |
| 60000 | - |
x * 59807, calculated, x * 60000, SDS-PAGE | Streptomyces griseus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Streptomyces griseus | enzyme is involved in fredericamycin biosynthesis | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces griseus | Q2MGB1 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CoA + apo-[fredericamycin H acyl-carrier protein] | - |
Streptomyces griseus | adenosine 3',5'-bisphosphate + holo-[fredericamycin acyl-carrier protein] | - |
? | |
| CoA + apo-[tetracenomycin M acyl-carrier protein] | - |
Streptomyces griseus | adenosine 3',5'-bisphosphate + holo-[tetracenomycin M acyl-carrier protein] | - |
? | |
| additional information | enzyme is involved in fredericamycin biosynthesis | Streptomyces griseus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 59807, calculated, x * 60000, SDS-PAGE | Streptomyces griseus |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.75 | - |
apo-[fredericamycin H acyl-carrier protein] | pH 8.0, 37°C | Streptomyces griseus | |
| 0.95 | - |
apo-[fredericamycin H acyl-carrier protein] | pH 8.0, 37°C | Streptomyces griseus | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Streptomyces griseus |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Streptomyces griseus | calculated | - |
12 |
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