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Literature summary for 2.7.8.5 extracted from

  • Hatch, G.M.; Gu, Y.; Xu, F.Y.; Cizeau, J.; Neumann, S.; Park, J.S.; Loewen, S.; Mowat, M.R.
    StARD13(Dlc-2) RhoGap mediates ceramide activation of phosphatidylglycerolphosphate synthase and drug response in Chinese hamster ovary cells (2008), Mol. Biol. Cell, 19, 1083-1092.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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Cricetulus griseus 5739
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate Cricetulus griseus cardiolipin (phospholipid) biosynthesis, regulation by short chain cell-permeable ceramide (C2-Cer: N-acetylsphingosine) signalling and levels of active GTP-bound RhoA phosphatidylglycerophosphate + CMP
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?

Organism

Organism UniProt Comment Textmining
Cricetulus griseus Q9Z2Z7 chinese hamster
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Source Tissue

Source Tissue Comment Organism Textmining
CHO-K1 cell chinese hamster ovary parental cell line (2.5fold induction of PGP synthase mRNA in response to N-acetylsphingosine-treatment, qRT-PCR) and etoposide-/N-acetylsphingosine-resistant cell line E91 (defect in ceramide signalling and RhoGAP activity, non-significant 1.2fold induction of PGP synthase mRNA in response to N-acetylsphingosine-treatment, qRT-PCR) Cricetulus griseus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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135% increased activity in parental CHO-K1 cell line, stably expressing dominant-negative RhoA(S19N), N-acetylsphingosine-treated, mitochondrial fraction Cricetulus griseus
additional information
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29% increased activity in CHO-K1 cell line E91, stably expressing dominant-negative RhoA(S19N), N-acetylsphingosine-treated, mitochondrial fraction Cricetulus griseus
additional information
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64% increased activity in TNFalpha-treated (1 h, 30 nM) parental CHO-K1 cell line, mitochondrial fraction Cricetulus griseus
additional information
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no change in activity in TNFalpha-treated (1 h, 30 nM) CHO-K1 cell line E91, mitochondrial fraction Cricetulus griseus
additional information
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slighty decreased constitutive activity in CHO-K1 cell line E91, stably expressing dominant-negative RhoA(S19N), mitochondrial fraction Cricetulus griseus
0.000191
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parental CHO-K1 cell line, mitochondrial fraction Cricetulus griseus
0.000192
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CHO-K1 cell line E91, mitochondrial fraction Cricetulus griseus
0.000197
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CHO-K1 cell line E91, N-acetylsphingosine-treated, no change in activity compared to untreated cells, mitochondrial fraction Cricetulus griseus
0.000299
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or 76% increased activity in parental CHO-K1 cell line, N-acetylsphingosine-treated, mitochondrial fraction Cricetulus griseus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate cardiolipin (phospholipid) biosynthesis, regulation by short chain cell-permeable ceramide (C2-Cer: N-acetylsphingosine) signalling and levels of active GTP-bound RhoA Cricetulus griseus phosphatidylglycerophosphate + CMP
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?
CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate in vitro assay on mitochondrial fractions of cells grown in presence or absence of 30-50 microM N-acetylsphingosine Cricetulus griseus phosphatidylglycerophosphate + CMP
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?

Synonyms

Synonyms Comment Organism
PGP synthase
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Cricetulus griseus
phosphatidylglycerolphosphate synthase
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Cricetulus griseus