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Literature summary for 2.7.8.5 extracted from

  • McMurray, W.C.; Jarvis, E.C.
    Purification and properties of phosphatidylglycerophosphate synthetase from mammalian liver mitochondria (1978), Can. J. Biochem., 56, 414-419.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
phosphatidylethanolamine stimulates, no stimulation by other diacylglycerophosphatides or lysophosphatides Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
Cd2+ strong inhibition at concentrations above 0.5 mM in presence of Mg2+ Sus scrofa
Co2+ Mn2+ or Co2+ stimulates at lower concentration, inhibition at higher concentration Sus scrofa
Cu2+ strong inhibition at concentrations above 0.5 mM in presence of Mg2+ Sus scrofa
Hg2+ strong inhibition at concentrations above 0.5 mM in presence of Mg2+ Sus scrofa
Mg2+ Mn2+ or Co2+ stimulates at lower concentration, inhibition at higher concentration Sus scrofa
Zn2+ strong inhibition at concentrations above 0.5 mM in presence of Mg2+ Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion membrane Rattus norvegicus 5739
-
mitochondrion membrane Sus scrofa 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ba2+ cation requirement is relatively nonspecific, Mg2+, Ba2+ or Ca2+ provides maximal activation in the 10 mM range, Mn2+ or Co2+ stimulates at lower concentration, inhibition at higher concentration Sus scrofa
Ca2+ cation requirement is relatively nonspecific, Mg2+, Ba2+ or Ca2+ provide maximal activation in the 10 mM range, Mn2+ or Co2+ stimulates at lower concentration, inhibition at higher concentration Sus scrofa
Co2+ cation requirement is relatively nonspecific, Mg2+, Ba2+ or Ca2+ provides maximal activation in the 10 mM range, Mn2+ or Co2+ stimulates at lower concentration, inhibition at higher concentration Sus scrofa
Mg2+ cation requirement is relatively nonspecific, Mg2+, Ba2+ or Ca2+ provide maximal activation in the 10 mM range, Mn2+ or Co2+ stimulates at lower concentration, inhibition at higher concentration Sus scrofa
Mn2+ cation requirement is relatively nonspecific, Mg2+, Ba2+ or Ca2+ provides maximal activation in the 10 mM range, Mn2+ or Co2+ stimulates at lower concentration, inhibition at higher concentration Sus scrofa

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CDP-diacylglycerol + sn-glycero-3-phosphate
-
Rattus norvegicus CMP + phosphatidylglycerophosphate
-
?
CDP-diacylglycerol + sn-glycero-3-phosphate
-
Sus scrofa CMP + phosphatidylglycerophosphate
-
?

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
37
-
assay at Sus scrofa