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Literature summary for 2.7.8.27 extracted from

  • Barcelo-Coblijn, G.; Martin, M.L.; de Almeida, R.F.; Noguera-Salva, M.A.; Marcilla-Etxenike, A.; Guardiola-Serrano, F.; Lueth, A.; Kleuser, B.; Halver, J.E.; Escriba, P.V.
    Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy (2011), Proc. Natl. Acad. Sci. USA, 108, 19569-19574.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
2-hydroxyoleic acid enzyme activity is 3.6fold higher than in untreated cells after 24 h of treatment with 0.2 mM 2-hydroxyoleic acid. Activity increases 85% after 5 min of treatment Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
D609 complete in inhibition at 0.35 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
1321-N1 cell
-
 Homo sapiens
-
A-549 cell
-
 Homo sapiens
-
JURKAT cell
-
 Homo sapiens
-
MRC-5 cell
-
 Homo sapiens
-
SF-767 cell
-
 Homo sapiens
-
U-118MG cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphatidylcholine + C6-ceramide
-
 Homo sapiens C6-sphingomyelin + 1,2-diacyl-sn-glycerol
-
 ?

Synonyms

Synonyms Comment Organism
SMS
-
 Homo sapiens