Inhibitors | Comment | Organism | Structure |
---|---|---|---|
caprazamycin B | - |
Bacillus subtilis | |
CPZEN-45 | CPZEN-45 strongly inhibits incorporation of radiolabeled glycerol into growing cultures and shows antibacterial activity against caprazamycin-resistant strains, including a strain overexpressing translocase-I MraY, involved in the biosynthesis of peptidoglycan, the target of the caprazamycins. Very poor inhibition by vancomycin | Bacillus subtilis | |
tunicamycin | - |
Bacillus subtilis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate | Bacillus subtilis | - |
UMP + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol | - |
? | |
UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate | Bacillus subtilis 168 | - |
UMP + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus subtilis | Q03521 | gene mraY | - |
Bacillus subtilis 168 | Q03521 | gene mraY | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate | - |
Bacillus subtilis | UMP + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol | - |
? | |
UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate | - |
Bacillus subtilis 168 | UMP + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MraY | - |
Bacillus subtilis |
translocase-I | - |
Bacillus subtilis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00005 | - |
pH and temperature not specified in the publication | Bacillus subtilis | caprazamycin B | |
0.0004 | - |
pH and temperature not specified in the publication | Bacillus subtilis | CPZEN-45 |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is involved in the biosynthesis of peptidoglycan | Bacillus subtilis |