Literature summary for 2.7.8.13 extracted from

Fujita, Y.; Murakami, R.; Muramatsu, Y.; Miyakoshi, S.; Takatsu, T.
A-94964, novel inhibitor of bacterial translocase I, produced by Streptomyces sp. SANK 60404. II. Physico-chemical properties and structure elucidation (2008), J. Antibiot., 61, 545-549.

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Application

Application	Comment	Organism
medicine	translocase I is a target of antibiotics	Staphylococcus aureus
medicine	translocase I is a target of antibiotics	Enterococcus faecalis

Inhibitors

Inhibitors	Comment	Organism	Structure
A-94964	-	Enterococcus faecalis
A-94964	-	Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate	Staphylococcus aureus	-	UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol	-	?
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate	Enterococcus faecalis	-	UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol	-	?

Organism

Organism	UniProt	Comment	Textmining
Enterococcus faecalis	-	-	-
Staphylococcus aureus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate	-	Staphylococcus aureus	UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol	-	?
UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate	-	Enterococcus faecalis	UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol	-	?

Synonyms

Synonyms	Comment	Organism
phospho-N-acetylmuramyl-pentapeptide translocase	-	Staphylococcus aureus
phospho-N-acetylmuramyl-pentapeptide translocase	-	Enterococcus faecalis
translocase I	-	Staphylococcus aureus
translocase I	-	Enterococcus faecalis

General Information

General Information	Comment	Organism
physiological function	translocase I is a key enzyme in peptidoglycan biosynthesis	Staphylococcus aureus
physiological function	translocase I is a key enzyme in peptidoglycan biosynthesis	Enterococcus faecalis

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Release 2023.1 (January 2023)