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Literature summary for 2.7.8.13 extracted from
- Initial membrane reaction in peptidoglycan synthesis. Interaction of lipid with phospho-N-acetylmuramyl-pentapeptide translocase (1979), Biochim. Biophys. Acta, 552, 418-427.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the physical state of the lipid microenvironment of the enzyme has a significant effect on the catalytic activity | Staphylococcus aureus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Staphylococcus aureus | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Staphylococcus aureus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-NAc-muramoyl-pentapeptide + acceptor | Staphylococcus aureus | first step in lipid cycle reactions in biosynthesis of bacterial cell wall peptidoglycans | UMP + acceptor-phospho-NAc-muramoyl-pentapeptide | - |
r | |
| UDP-NAc-muramoyl-pentapeptide + acceptor | Staphylococcus aureus Copenhagen | first step in lipid cycle reactions in biosynthesis of bacterial cell wall peptidoglycans | UMP + acceptor-phospho-NAc-muramoyl-pentapeptide | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Staphylococcus aureus | - |
Copenhagen | - |
| Staphylococcus aureus Copenhagen | - |
Copenhagen | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-N-acetylmuramoyl-pentapeptide + [2H]UMP | - |
Staphylococcus aureus | UMP + [2H]UDP-NAc-muramoyl-pentapeptide | - |
r | |
| UDP-N-acetylmuramoyl-pentapeptide + [2H]UMP | - |
Staphylococcus aureus Copenhagen | UMP + [2H]UDP-NAc-muramoyl-pentapeptide | - |
r | |
| UDP-NAc-muramoyl-pentapeptide + acceptor | - |
Staphylococcus aureus | UMP + acceptor-phospho-NAc-muramoyl-pentapeptide | - |
r | |
| UDP-NAc-muramoyl-pentapeptide + acceptor | first step in lipid cycle reactions in biosynthesis of bacterial cell wall peptidoglycans | Staphylococcus aureus | UMP + acceptor-phospho-NAc-muramoyl-pentapeptide | - |
r | |
| UDP-NAc-muramoyl-pentapeptide + acceptor | - |
Staphylococcus aureus Copenhagen | UMP + acceptor-phospho-NAc-muramoyl-pentapeptide | - |
r | |
| UDP-NAc-muramoyl-pentapeptide + acceptor | first step in lipid cycle reactions in biosynthesis of bacterial cell wall peptidoglycans | Staphylococcus aureus Copenhagen | UMP + acceptor-phospho-NAc-muramoyl-pentapeptide | - |
r | |
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