KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.016 | - |
UDP-MurNAc-Ala-D-Glu-Orn-D-Ala-D-Ala | pH 7.8, 37°C, exchange reaction | Staphylococcus aureus | |
0.02 | - |
UDP-MurNAc-Ala-D-Glu-Lys-D-Ala-D-Ala | pH 7.8, 37°C, exchange reaction | Staphylococcus aureus | |
0.022 | - |
UDP-MurNAc-Ala-D-Glu-Dap-D-Ala-D-Ala | pH 7.8, 37°C, exchange reaction | Staphylococcus aureus | |
0.029 | - |
UDP-MurNAc-Ala-D-Glu-Lys-D-Ala-Gly | pH 7.8, 37°C, exchange reaction | Staphylococcus aureus | |
0.044 | - |
UDP-MurNAc-Gly-D-Glu-Lys-D-Ala-D-Ala | pH 7.8, 37°C, exchange reaction | Staphylococcus aureus | |
0.055 | - |
UDP-MurNAc-Ala-D-Glu-Lys-D-Ala-D-Ala | pH 7.8, 37°C, ransfer reaction | Staphylococcus aureus | |
0.058 | - |
UDP-MurNAc-Ala-D-Glu-Lys-D-Ala | pH 7.8, 37°C, exchange reaction | Staphylococcus aureus | |
0.063 | - |
UDP-MurNAc-Ala-D-Glu-Lys-Gly-D-Ala | pH 7.8, 37°C, exchange reaction | Staphylococcus aureus | |
0.08 | - |
UDP-MurNAc-Gly-D-Glu-Lys-D-Ala-D-Ala | pH 7.8, 37°C, exchange reaction | Staphylococcus aureus | |
0.083 | - |
UDP-MurNAc-Ala-D-Glu-D-Ala-Glu | pH 7.8, 37°C, transfer reaction | Staphylococcus aureus | |
0.1 | - |
UDP-MurNAc-Ala-D-Glu-mDap-D-Ala-D-Ala | pH 7.8, 37°C, transfer reaction | Staphylococcus aureus | |
0.18 | - |
UDP-MurNAc-Ala-D-Glu-Lys | pH 7.8, 37°C | Staphylococcus aureus | |
0.4 | - |
UDP-MurNAc-Ala-D-Glu-Lys-D-Ala | pH 7.8, 37°C, transfer reaction | Staphylococcus aureus | |
0.44 | - |
UDP-MurNAc-Ala-D-Glu-Lys-Gly-D-Ala | pH 7.8, 37°C, transfer reaction | Staphylococcus aureus | |
0.5 | - |
UDP-MurNAc-Gly-D-Glu-Lys-D-Ala-D-Ala | pH 7.8, 37°C, transfer reaction | Staphylococcus aureus | |
4.4 | - |
UDP-MurNAc-Ala-Glu-Lys | pH 7.8, 37°C, transfer reaction | Staphylococcus aureus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-NAc-muramoyl-pentapeptide + acceptor | Staphylococcus aureus | initial stage in peptidoglycan synthesis, key role in selecting analogs of UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla, membrane associated reaction of cell wall biosynthesis | UMP + acceptor-phospho-NAc-muramoyl-pentapeptide | - |
r | |
UDP-NAc-muramoyl-pentapeptide + acceptor | Staphylococcus aureus Copenhagen | initial stage in peptidoglycan synthesis, key role in selecting analogs of UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla, membrane associated reaction of cell wall biosynthesis | UMP + acceptor-phospho-NAc-muramoyl-pentapeptide | - |
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Organism | UniProt | Comment | Textmining |
---|---|---|---|
Staphylococcus aureus | - |
Copenhagen | - |
Staphylococcus aureus Copenhagen | - |
Copenhagen | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-MurNAc-Ala-D-Glu-Lys + undecaprenyl phosphate | - |
Staphylococcus aureus | UMP + MurNAc-Ala-D-Glu-Lys-diphosphoundecaprenol | - |
? | |
UDP-MurNAc-Ala-D-Glu-Lys + undecaprenyl phosphate | - |
Staphylococcus aureus Copenhagen | UMP + MurNAc-Ala-D-Glu-Lys-diphosphoundecaprenol | - |
? | |
UDP-MurNAc-Ala-D-Glu-Lys-D-Ala + undecaprenyl phosphate | - |
Staphylococcus aureus | UMP + MurNAc-Ala-D-Glu-Lys-D-Ala-diphosphoundecaprenol | - |
? | |
UDP-MurNAc-Ala-D-Glu-Lys-D-Ala + undecaprenyl phosphate | - |
Staphylococcus aureus Copenhagen | UMP + MurNAc-Ala-D-Glu-Lys-D-Ala-diphosphoundecaprenol | - |
? | |
UDP-MurNAc-Ala-D-Glu-Lys-D-Ala-Gly + undecaprenyl phosphate | - |
Staphylococcus aureus | UMP + MurNAc-Ala-D-Glu-Lys-D-Ala-Gly-diphosphoundecaprenol | - |
? | |
UDP-MurNAc-Ala-D-Glu-Lys-Gly-D-Ala + undecaprenyl phosphate | - |
Staphylococcus aureus | UMP + MurNAc-Ala-D-Glu-Lys-Gly-D-Ala-diphosphoundecaprenol | - |
? | |
UDP-MurNAc-Ala-D-Glu-Orn-D-Ala-D-Ala + undecaprenyl phosphate | - |
Staphylococcus aureus | UMP + MurNAc-Ala-D-Glu-Orn-D-Ala-D-Ala-diphosphoundecaprenol | - |
? | |
UDP-MurNAc-Ala-Glu-Lys + undecaprenyl phosphate | - |
Staphylococcus aureus | UMP + MurNAc-Ala-Glu-Lys-diphosphoundecaprenol | - |
? | |
UDP-MurNAc-Gly-D-Glu-Lys-D-Ala-D-Ala + undecaprenyl phosphate | - |
Staphylococcus aureus | UMP + MurNAc-Gly-D-Glu-Lys-D-Ala-D-Ala-diphosphoundecaprenol | - |
? | |
UDP-MurNAc-pentapeptide + undecaprenoid-1-ol-phosphate | UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala + lipid phosphate, specificity profile towards peptide subunit | Staphylococcus aureus | lipid-P-P-MurNAc-pentapeptide + UMP | - |
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UDP-MurNAc-pentapeptide + undecaprenoid-1-ol-phosphate | UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala + lipid phosphate, specificity profile towards peptide subunit | Staphylococcus aureus Copenhagen | lipid-P-P-MurNAc-pentapeptide + UMP | - |
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UDP-NAc-muramoyl-pentapeptide + acceptor | - |
Staphylococcus aureus | UMP + acceptor-phospho-NAc-muramoyl-pentapeptide | - |
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UDP-NAc-muramoyl-pentapeptide + acceptor | initial stage in peptidoglycan synthesis, key role in selecting analogs of UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla, membrane associated reaction of cell wall biosynthesis | Staphylococcus aureus | UMP + acceptor-phospho-NAc-muramoyl-pentapeptide | - |
r | |
UDP-NAc-muramoyl-pentapeptide + acceptor | - |
Staphylococcus aureus Copenhagen | UMP + acceptor-phospho-NAc-muramoyl-pentapeptide | - |
r | |
UDP-NAc-muramoyl-pentapeptide + acceptor | initial stage in peptidoglycan synthesis, key role in selecting analogs of UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla, membrane associated reaction of cell wall biosynthesis | Staphylococcus aureus Copenhagen | UMP + acceptor-phospho-NAc-muramoyl-pentapeptide | - |
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