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Literature summary for 2.7.8.13 extracted from

  • Hammes, W.P.; Neuhaus, F.C.
    On the specificity of phospho-N-acetylmuramyl-pentapeptide translocase. The peptide subunit of uridine diphosphate-N-actylmuramyl-pentapeptide (1974), J. Biol. Chem., 249, 3140-3150.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.016
-
UDP-MurNAc-Ala-D-Glu-Orn-D-Ala-D-Ala pH 7.8, 37°C, exchange reaction Staphylococcus aureus
0.02
-
UDP-MurNAc-Ala-D-Glu-Lys-D-Ala-D-Ala pH 7.8, 37°C, exchange reaction Staphylococcus aureus
0.022
-
UDP-MurNAc-Ala-D-Glu-Dap-D-Ala-D-Ala pH 7.8, 37°C, exchange reaction Staphylococcus aureus
0.029
-
UDP-MurNAc-Ala-D-Glu-Lys-D-Ala-Gly pH 7.8, 37°C, exchange reaction Staphylococcus aureus
0.044
-
UDP-MurNAc-Gly-D-Glu-Lys-D-Ala-D-Ala pH 7.8, 37°C, exchange reaction Staphylococcus aureus
0.055
-
UDP-MurNAc-Ala-D-Glu-Lys-D-Ala-D-Ala pH 7.8, 37°C, ransfer reaction Staphylococcus aureus
0.058
-
UDP-MurNAc-Ala-D-Glu-Lys-D-Ala pH 7.8, 37°C, exchange reaction Staphylococcus aureus
0.063
-
UDP-MurNAc-Ala-D-Glu-Lys-Gly-D-Ala pH 7.8, 37°C, exchange reaction Staphylococcus aureus
0.08
-
UDP-MurNAc-Gly-D-Glu-Lys-D-Ala-D-Ala pH 7.8, 37°C, exchange reaction Staphylococcus aureus
0.083
-
UDP-MurNAc-Ala-D-Glu-D-Ala-Glu pH 7.8, 37°C, transfer reaction Staphylococcus aureus
0.1
-
UDP-MurNAc-Ala-D-Glu-mDap-D-Ala-D-Ala pH 7.8, 37°C, transfer reaction Staphylococcus aureus
0.18
-
UDP-MurNAc-Ala-D-Glu-Lys pH 7.8, 37°C Staphylococcus aureus
0.4
-
UDP-MurNAc-Ala-D-Glu-Lys-D-Ala pH 7.8, 37°C, transfer reaction Staphylococcus aureus
0.44
-
UDP-MurNAc-Ala-D-Glu-Lys-Gly-D-Ala pH 7.8, 37°C, transfer reaction Staphylococcus aureus
0.5
-
UDP-MurNAc-Gly-D-Glu-Lys-D-Ala-D-Ala pH 7.8, 37°C, transfer reaction Staphylococcus aureus
4.4
-
UDP-MurNAc-Ala-Glu-Lys pH 7.8, 37°C, transfer reaction Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-NAc-muramoyl-pentapeptide + acceptor Staphylococcus aureus initial stage in peptidoglycan synthesis, key role in selecting analogs of UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla, membrane associated reaction of cell wall biosynthesis UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor Staphylococcus aureus Copenhagen initial stage in peptidoglycan synthesis, key role in selecting analogs of UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla, membrane associated reaction of cell wall biosynthesis UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
r

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
Copenhagen
-
Staphylococcus aureus Copenhagen
-
Copenhagen
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-MurNAc-Ala-D-Glu-Lys + undecaprenyl phosphate
-
Staphylococcus aureus UMP + MurNAc-Ala-D-Glu-Lys-diphosphoundecaprenol
-
?
UDP-MurNAc-Ala-D-Glu-Lys + undecaprenyl phosphate
-
Staphylococcus aureus Copenhagen UMP + MurNAc-Ala-D-Glu-Lys-diphosphoundecaprenol
-
?
UDP-MurNAc-Ala-D-Glu-Lys-D-Ala + undecaprenyl phosphate
-
Staphylococcus aureus UMP + MurNAc-Ala-D-Glu-Lys-D-Ala-diphosphoundecaprenol
-
?
UDP-MurNAc-Ala-D-Glu-Lys-D-Ala + undecaprenyl phosphate
-
Staphylococcus aureus Copenhagen UMP + MurNAc-Ala-D-Glu-Lys-D-Ala-diphosphoundecaprenol
-
?
UDP-MurNAc-Ala-D-Glu-Lys-D-Ala-Gly + undecaprenyl phosphate
-
Staphylococcus aureus UMP + MurNAc-Ala-D-Glu-Lys-D-Ala-Gly-diphosphoundecaprenol
-
?
UDP-MurNAc-Ala-D-Glu-Lys-Gly-D-Ala + undecaprenyl phosphate
-
Staphylococcus aureus UMP + MurNAc-Ala-D-Glu-Lys-Gly-D-Ala-diphosphoundecaprenol
-
?
UDP-MurNAc-Ala-D-Glu-Orn-D-Ala-D-Ala + undecaprenyl phosphate
-
Staphylococcus aureus UMP + MurNAc-Ala-D-Glu-Orn-D-Ala-D-Ala-diphosphoundecaprenol
-
?
UDP-MurNAc-Ala-Glu-Lys + undecaprenyl phosphate
-
Staphylococcus aureus UMP + MurNAc-Ala-Glu-Lys-diphosphoundecaprenol
-
?
UDP-MurNAc-Gly-D-Glu-Lys-D-Ala-D-Ala + undecaprenyl phosphate
-
Staphylococcus aureus UMP + MurNAc-Gly-D-Glu-Lys-D-Ala-D-Ala-diphosphoundecaprenol
-
?
UDP-MurNAc-pentapeptide + undecaprenoid-1-ol-phosphate UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala + lipid phosphate, specificity profile towards peptide subunit Staphylococcus aureus lipid-P-P-MurNAc-pentapeptide + UMP
-
r
UDP-MurNAc-pentapeptide + undecaprenoid-1-ol-phosphate UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala + lipid phosphate, specificity profile towards peptide subunit Staphylococcus aureus Copenhagen lipid-P-P-MurNAc-pentapeptide + UMP
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
-
Staphylococcus aureus UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor initial stage in peptidoglycan synthesis, key role in selecting analogs of UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla, membrane associated reaction of cell wall biosynthesis Staphylococcus aureus UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor
-
Staphylococcus aureus Copenhagen UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor initial stage in peptidoglycan synthesis, key role in selecting analogs of UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla, membrane associated reaction of cell wall biosynthesis Staphylococcus aureus Copenhagen UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
r