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Literature summary for 2.7.7.B22 extracted from

  • Marzo, M.; Liu, D.; Ruiz, A.; Chalmers, R.
    Identification of multiple binding sites for the THAP domain of the Galileo transposase in the long terminal inverted-repeats (2013), Gene, 525, 84-91.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.B22

Cloned(Commentary)

Cloned (Comment) Organism
Galileo gene structure comparisons in Drosophila species, overview Drosophila buzzatii

Organism

Organism UniProt Comment Textmining
Drosophila buzzatii
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information identification of multiple DNA binding sites for the THAP domain of the Galileo transposase in the long terminal inverted-repeats, these TIRs and other Foldback-like elements may provide the transposase with its binding specificity Drosophila buzzatii ?
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Subunits

Subunits Comment Organism
More in contrast to other members of the P-element superfamily, it has unusually long terminal inverted-repeats (TIRs) that resemble those of Foldback elements. The synaptic complex between Galileo ends may be a complicated structure containing higher-order multimers of the transposase Drosophila buzzatii

Synonyms

Synonyms Comment Organism
DbuzGalileo
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 Drosophila buzzatii
Galileo transposase
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 Drosophila buzzatii

General Information

General Information Comment Organism
evolution the enzyme Galileo is a members of the P-element superfamily. In contrast to other members of the P-element superfamily, it has unusually long terminal inverted-repeats (TIRs) that resemble those of Foldback elements. Different subfamilies of Galileo exist, known as DbuzGalileo-K and DbuzGalileo-N,while DbuzGalileo-G denotes the subfamily of the synthetic element. The various Galileo subfamilies have TIRs of different lengths, but share significant sequence homologies at the tips of the elements where one might expect the transposase to bind. Comparison of THAP domain protein sequences and cross-reactivity between the subfamilies, overview Drosophila buzzatii
physiological function Galileo is a DNA transposon responsible for the generation of several chromosomal inversions in Drosophila Drosophila buzzatii