Cloned (Comment) | Organism |
---|---|
- |
Leishmania major |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.07 | - |
UTP | pH 7.8, 25°C | Leishmania major | |
0.105 | - |
UDP-glucose | pH 7.8, 25°C | Leishmania major | |
0.192 | - |
alpha-D-glucose 1-phosphate | pH 7.8, 25°C | Leishmania major | |
0.2 | - |
diphosphate | pH 7.8, 25°C | Leishmania major |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
54500 | - |
1 * 54500, calculated and SDS-PAGE | Leishmania major |
59000 | - |
gel filtration | Leishmania major |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania major | Q4QDU3 | - |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose | ordered bi-bi mechanism. The molecular geometry at position 4 of glucose is responsible for substrate specificity. The gamma-phosphate group of UTP is essential for binding and for induction of the open conformation, which then allows entry of glucose 1-phosphate | Leishmania major |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
diphosphate + UDP-glucose | - |
Leishmania major | UTP + alpha-D-glucose 1-phosphate | - |
r | |
additional information | molecular geometry at position 4 of glucose is responsible for substrate specificity. The gamma-phosphate group of UTP is essential for binding and for induction of the open conformation, which then allows entry of glucose 1-phosphate | Leishmania major | ? | - |
? | |
UTP + alpha-D-glucose 1-phosphate | - |
Leishmania major | diphosphate + UDP-glucose | - |
r |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 54500, calculated and SDS-PAGE | Leishmania major |