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Literature summary for 2.7.7.86 extracted from

  • Xu, Q.; Xiong, H.; Zhu, W.; Liu, Y.; Du, Y.
    Small molecule inhibition of cyclic GMP-AMP synthase ameliorates sepsis-induced cardiac dysfunction in mice (2020), Life Sci., 260, 118315 .
    View publication on PubMed
Search for more literature for 2.7.7.86

Inhibitors

Inhibitors Comment Organism Structure
3-[1-(6,7-dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-pyrazol-4-yl]-3H-isobenzofuran-1-one RU-521 or RU.521, markedly mitigates the inflammatory responses, oxidative stress and apoptosis in hearts of sepsis mice. RU.521 attenuates myocardial apoptosis in the hearts of mice with sepsis Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + GTP Mus musculus overall reaction 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8C6L5
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + GTP overall reaction Mus musculus 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5')
-
 ?

Synonyms

Synonyms Comment Organism
cGAS
-
 Mus musculus

General Information

General Information Comment Organism
malfunction small molecule inhibition of cyclic GMP-AMP synthase by RU.521 ameliorates sepsis-induced cardiac dysfunction in mice. The inflammatory responses, oxidative stress and apoptosis in hearts of sepsis mice are markedly mitigated by RU.521. The septic mice that undergo RU.521 treatment exhibit suppressed myocardial apoptosis, which is indicated by decreased caspase-3 activity Mus musculus
physiological function key role of cGAS in sepsis-induced cardiac injury Mus musculus