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Literature summary for 2.7.7.84 extracted from

  • Liao, X.; Xie, H.; Li, S.; Ye, H.; Li, S.; Ren, K.; Li, Y.; Xu, M.; Lin, W.; Duan, X.; Yang, C.; Chen, L.
    2',5'-Oligoadenylate synthetase 2 (OAS2) inhibits Zika virus replication through activation of type I IFN signaling pathway (2020), Viruses, 12, 418 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.84

Cloned(Commentary)

Cloned (Comment) Organism
gene OAS2, DNA and amino acid sequencing, RNA sequence library production, and complete transcriptome analysis of A549 cells with and without Zika virus (ZIKV) infection, quantitative real-time PCR expression analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information OAS2 knockdown increases ZIKV replication. Overexpression of OAS2 modestly increases the IFN-induced p-STAT1 both with IFN treatment and without IFN treatment compared to control. OAS2 overexpression also increases ISRE activity and some classical ISGs expression including Myxovirus resistance-A (MxA) and interferon-induced protein 2 (IFIT2) Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 ATP Homo sapiens
-
 pppA2'p5'A2'p5'A + 2 diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P29728
-
-

Source Tissue

Source Tissue Comment Organism Textmining
2fTGH cell
-
 Homo sapiens
-
A-549 cell
-
 Homo sapiens
-
Huh-7 cell
-
 Homo sapiens
-
Huh-7.5.1 cell
-
 Homo sapiens
-
U-5A cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 ATP
-
 Homo sapiens pppA2'p5'A2'p5'A + 2 diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
2',5'-oligoadenylate synthetase 2
-
 Homo sapiens
OAS2
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens ZIKV infection induces OAS2 expression through a RIG-I-dependent pathway up

General Information

General Information Comment Organism
malfunction OAS2 knockdown increases ZIKV replication. Overexpression of OAS2 modestly increases the IFN-induced p-STAT1 both with IFN treatment and without IFN treatment compared to control. OAS2 overexpression also increases ISRE activity and some classical ISGs expression including Myxovirus resistance-A (MxA) and interferon-induced protein 2 (IFIT2) Homo sapiens
metabolism the human 2',5'-oligoadenylate synthetase (OAS) are IFN-induced genes that play an essential role in the antiviral activity of IFNs. The OAS family is composed of four gene members, including OAS1, OAS2, OAS3, and OAS-like protein (OASL), differing in numbers of OAS domain, type of synthesized 2-5A and oligomerization level Homo sapiens
physiological function 2',5'-oligoadenylate synthetase 2 (OAS2) inhibits Zika virus replication through activation of type I IFN signaling pathway. ZIKV infection induces OAS2 expression through a RIG-I-dependent pathway. OAS2 overexpression inhibits ZIKV replication, while OAS2 knockdown increases ZIKV replication. OAS2 inhibits ZIKV replication through enhanced IFNbeta expression, leading to the activation of the Jak/STAT signaling pathway Homo sapiens