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Literature summary for 2.7.7.8 extracted from

  • Wang, D.D.; Shu, Z.; Lieser, S.A.; Chen, P.L.; Lee, W.H.
    Human mitochondrial SUV3 and polynucleotide phosphorylase form a 330-kDa heteropentamer to cooperatively degrade double-stranded RNA with a 3'-to-5' directionality (2009), J. Biol. Chem., 284, 20812-20821.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.8

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Rosetta cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
207600
-
 equilibrium sedimentation analytical ultracentrifugation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
MonoQ colmn chromatography, metal ion affinity chromatography, and Superdex 200 gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information suppressor of Var1 3 and polynucleotide phosphorylase form a 330-kDa heteropentamer that is capable of efficiently degrading double-stranded RNA substrates in the presence of ATP, the hSUV3-PNPase complex prefers substrates containing a 3' overhang and degrades the RNA in a 3'-to-5' directionality Homo sapiens ?
-
 ?
poly(A) + ADP
-
 Homo sapiens poly(A)+1 + phosphate
-
 ?

Subunits

Subunits Comment Organism
trimer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
PNPase
-
 Homo sapiens
polynucleotide phosphorylase
-
 Homo sapiens