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Literature summary for 2.7.7.8 extracted from

  • Rosenzweig, J.A.; Chromy, B.; Echeverry, A.; Yang, J.; Adkins, B.; Plano, G.V.; McCutchen-Maloney, S.; Schesser, K.
    Polynucleotide phosphorylase independently controls virulence factor expression levels and export in Yersinia spp. (2007), FEMS Microbiol. Lett., 270, 255-264.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information enzyme deletion strain is less virulent in mouse than the isogenic wild-type. Enzyme deletion strains show enhanced levels of type III secretion system T3SS encoding transcripts and proteins. T3SS expression levels do not differ between enzyme deletion strains expressing active and inactive S1 RNA binding domain of enzyme which is required for normal T3SS activity Yersinia sp.
additional information polynucleotide phosphorylase deletion strain is less virulent in mouse compared with the isogenic wild-type strain. Deletion strains possess enhanced levels of type III secretion system-encoding transcripts and proteins. A S1 variant of polynucleotide phosphorylase containing a disruption in its RNA-binding subdomain cannot restore normal type III secretion system activity Yersinia sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Yersinia sp. enzyme affects the expression and activity of the type III secretion system by distinct mechanisms. the RNA-binding subdomain S1-dependent effect on type III secretion system involves an RNA intermediate ?
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Organism

Organism UniProt Comment Textmining
Yersinia sp.
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme affects the expression and activity of the type III secretion system by distinct mechanisms. the RNA-binding subdomain S1-dependent effect on type III secretion system involves an RNA intermediate Yersinia sp. ?
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?