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Literature summary for 2.7.7.7 extracted from

  • Wang, L.; Broyde, S.
    A new anti conformation for N-(deoxyguanosin-8-yl)-2-acetylaminofluorene (AAF-dG) allows Watson-Crick pairing in the Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4) (2006), Nucleic Acids Res., 34, 785-795.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.7

Organism

Organism UniProt Comment Textmining
Saccharolobus solfataricus Q97W02
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Saccharolobus solfataricus P2 Q97W02
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn the enzyme can preferentially insert C opposite N-(deoxyguanosin-8-yl)-2-acetylaminofluorene. An anti glycosidic torsion with C1'-exo deoxyribose conformation allows N-(deoxyguanosin-8-yl)-2-acetylaminofluorene to be Watson–Crick hydrogen-bonded with dCTP with modest polymerase perturbation, but other nucleotides are more distorting Saccharolobus solfataricus ?
-
 ?
deoxynucleoside triphosphate + DNAn the enzyme can preferentially insert C opposite N-(deoxyguanosin-8-yl)-2-acetylaminofluorene. An anti glycosidic torsion with C1'-exo deoxyribose conformation allows N-(deoxyguanosin-8-yl)-2-acetylaminofluorene to be Watson–Crick hydrogen-bonded with dCTP with modest polymerase perturbation, but other nucleotides are more distorting Saccharolobus solfataricus P2 ?
-
 ?

Synonyms

Synonyms Comment Organism
DNA polymerase IV
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 Saccharolobus solfataricus
Dpo4
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 Saccharolobus solfataricus