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Literature summary for 2.7.7.7 extracted from
- Influence of local sequence context on damaged base conformation in human DNA polymerase iota: molecular dynamics studies of nucleotide incorporation opposite a benzo[a]pyrene-derived adenine lesion (2009), Nucleic Acids Res., 37, 7095-7109.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9UNA4 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| deoxynucleoside triphosphate + DNAn | with undamaged templating purines DNA polymerase iota normally favors Hoogsteen base pairing, DNA polymerase iota can incorporate nucleotides opposite a benzo[a]pyrene-derived adenine lesion | Homo sapiens | diphosphate + DNAn+1 | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DNA polymerase iota | - |
Homo sapiens |
| pol iota | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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