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Literature summary for 2.7.7.7 extracted from

  • Loeb, L.A.; Monnat, R.J.
    DNA polymerases and human disease (2008), Nat. Rev. Genet., 9, 594-604.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
Homo sapiens diphosphate + DNAn+1
-
?

Synonyms

Synonyms Comment Organism
DNA polymerase
-
Homo sapiens
pol alpha isozyme Homo sapiens
pol beta isozyme Homo sapiens
pol delta isozyme Homo sapiens
POl epsilon isozyme Homo sapiens
Pol eta isozyme Homo sapiens
Pol gamma isozyme Homo sapiens
pol iota isozyme Homo sapiens
pol kappa isozyme Homo sapiens
Pol lambda isozyme Homo sapiens
Pol mu isozyme Homo sapiens
Pol theta isozyme Homo sapiens
Pol zeta isozyme Homo sapiens
Rec1
-
Homo sapiens

General Information

General Information Comment Organism
malfunction mutations in or altered expression of Pol gamma coupled with oxidative damage to mitochondrial DNA may be involved in Parkinson disease and Alzheimer disease Homo sapiens
physiological function Pol alpha catalyses initiation of chromosomal DNA replication at origins and at Okazaki fragments on the lagging strand, Pol beta participates in base-excision repair, Pol gamma catalyses mitochondrial DNA synthetic processes, Pol delta participates in lagging-strand synthesis, and Pol epsilon has a role in the synthesis of the leading strand of chromosomal DNA, Pol eta functions in bypass UV lesions,Pol iota, Pol kappa, and Pol zeta function in bypass synthesis, Pol lambda functions in base excision repair, Pol mu functions in non-homologous end joining, Pol theta functions in DNA repair, and DNA polymerase Rec1 incorporates dC opposite abasic sites. Pol beta can be classified as a tumour suppressor Homo sapiens