Literature summary for 2.7.7.7 extracted from

Palud, A.; Villani, G.; LHaridon, S.; Querellou, J.; Raffin, J.P.; Henneke, G.
Intrinsic properties of the two replicative DNA polymerases of Pyrococcus abyssi in replicating abasic sites: possible role in DNA damage tolerance? (2008), Mol. Microbiol., 70, 746-761.

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Organism

Organism	UniProt	Comment	Textmining
Pyrococcus abyssi	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
deoxynucleoside triphosphate + DNAn	polB and polD preferentially insert dAMP opposite an apurinic/apyrimidinic site, albeit inefficiently	Pyrococcus abyssi	diphosphate + DNAn+1	-	?

Synonyms

Synonyms	Comment	Organism
DNA polymerase	-	Pyrococcus abyssi
PolB	replicative DNA polymerase	Pyrococcus abyssi
polD	replicative DNA polymerase	Pyrococcus abyssi

General Information

General Information	Comment	Organism
physiological function	DNA polymerases have abortive DNA synthesis upon encountering apurinic/apyrimidinic sites. Under running start conditions, polB can incorporate in front of the damage and even replicate to the full-length oligonucleotides containing a specific apurinic/apyrimidinic site, but only when present at a molar excess. Conversely, bypassing activity of polD is strictly inhibited	Pyrococcus abyssi

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Release 2023.1 (January 2023)