Protein Variants | Comment | Organism |
---|---|---|
E200A | exonuclease-deficient mutant | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
gemcitabine | i.e. 2'-deoxy-2',2'-difluorocytidine, when gemcitabine is encountered as a template base DNA polymerase gamma pauses at the lesion and one downstream position but eventually elongates the primer to full-length product, these pauses are because of a 1000fold decrease in nucleotide incorporation efficiency | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxynucleoside triphosphate + DNAn | - |
Homo sapiens | diphosphate + DNAn+1 | - |
? | |
additional information | the excision of the matched 3'-monophosphorylated form of 2'-deoxy-2',2'-difluorocytidine moiety by the wild type pol gamma is 55fold slower than the excision of matched 3'-dCMP | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DNA polymerase gamma | - |
Homo sapiens |
Pol gamma | - |
Homo sapiens |