Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,3-bis[2-chloroethyl]-2-nitrosourea | - |
Homo sapiens | |
cloretazine | i.e. 1,2-bis[methylsulfonyl]-1-[2-chloroethyl]-2-[(methylamino)carbonyl]hydrazine | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxynucleoside triphosphate + DNAn | - |
Homo sapiens | diphosphate + DNAn+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DNA polymerase beta | - |
Homo sapiens |
Klenow fragment | - |
Homo sapiens |
pol beta | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.074 | - |
Pol beta, at 25°C, pH 8.0 | Homo sapiens | cloretazine | |
0.092 | - |
Pol beta, at 25°C, pH 8.0 | Homo sapiens | 1,2-bis[methylsulfonyl]-1-[(methylamino)carbonyl]hydrazine | |
0.271 | - |
Pol beta, at 25°C, pH 8.0 | Homo sapiens | 1,3-bis[2-chloroethyl]-2-nitrosourea | |
0.307 | - |
Klenow fragment, at 25°C, pH 8.0 | Homo sapiens | 1,2-bis[methylsulfonyl]-1-[(methylamino)carbonyl]hydrazine | |
0.387 | - |
Klenow fragment, at 25°C, pH 8.0 | Homo sapiens | cloretazine | |
1.435 | - |
Klenow fragment, at 25°C, pH 8.0 | Homo sapiens | 1,3-bis[2-chloroethyl]-2-nitrosourea |
General Information | Comment | Organism |
---|---|---|
physiological function | Pol beta is a DNA polymerase specific to base excision repair that also possesses lyase activity capable of severing the phosphoester bond on the 3' carbon of the abasic ribose | Homo sapiens |