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Literature summary for 2.7.7.7 extracted from
- Quantum mechanics/molecular mechanics investigation of the chemical reaction in Dpo4 reveals water-dependent pathways and requirements for active site reorganization (2008), J. Am. Chem. Soc., 130, 13240-13250.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharolobus solfataricus | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1 | nucleotidyl-transfer reaction mechanism, intermediate structures and energy profiles, overview | Saccharolobus solfataricus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| deoxynucleoside triphosphate + DNAn | the nucleotidyl-transfer reaction coupled with the conformational transitions in DNA polymerases is critical for maintaining the fidelity and efficiency of DNA synthesis, correct insertion of dCTP opposite 8-oxoguanine and quantum mechanics/molecular mechanics investigation of the chemical reaction in Dpo4 reveals water-dependent pathways and requirements for active site reorganization, overview | Saccharolobus solfataricus | diphosphate + DNAn+1 | - |
? |  |
| additional information | simulation model of the solvated Dpo4/DNA/8-oxoG:dCTP complex, catalytic site structure, overview | Saccharolobus solfataricus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DNA polymerase IV | - |
Saccharolobus solfataricus |
| Dpo4 | - |
Saccharolobus solfataricus |
| More | the enzyme belongs to the Y-family polymerases | Saccharolobus solfataricus |
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