Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Allicin | - |
Homo sapiens | |
Allicin | - |
Rattus norvegicus | |
alliin | - |
Homo sapiens | |
alliin | - |
Rattus norvegicus | |
diallyl pentasulfide | - |
Homo sapiens | |
diallyl pentasulfide | - |
Rattus norvegicus | |
diallyl tetrasulfide | - |
Homo sapiens | |
diallyl tetrasulfide | - |
Rattus norvegicus | |
diallyl trisulfide | - |
Homo sapiens | |
diallyl trisulfide | - |
Rattus norvegicus | |
additional information | DNA polymerase alpha is not inhibited by allicin, alliin, diallyl trisulfide, diallyl tetrasulfide, and diallyl pentasulfide | Bos taurus | |
additional information | DNA polymerase isozymes I and II are not inhibited by diallyl trisulfide, diallyl tetrasulfide, and diallyl pentasulfide | Brassica oleracea | |
additional information | DNA polymerase isozymes alpha, delta and epsilon are not inhibited by diallyl trisulfide, diallyl tetrasulfide, and diallyl pentasulfide | Drosophila melanogaster | |
additional information | DNA polymerase I is not inhibited by diallyl trisulfide, diallyl tetrasulfide, and diallyl pentasulfide | Escherichia coli | |
additional information | DNA polymerase lambda is strongly inhibited by an extract from Allium sativum consisting of diallyl trisulfide, diallyl tetrasulfide, and diallyl pentasulfide, competitive inhibitor | Homo sapiens | |
additional information | DNA polymerase delta is not inhibited by diallyl trisulfide, diallyl tetrasulfide, and diallyl pentasulfide | Oncorhynchus masou | |
additional information | DNA polymerase beta is strongly inhibited by an extract from Allium sativum consisting of diallyl trisulfide, diallyl tetrasulfide, and diallyl pentasulfide, competitive inhibitor | Rattus norvegicus | |
additional information | DNA polymerase is not inhibited by diallyl trisulfide, diallyl tetrasulfide, and diallyl pentasulfide | Tequatrovirus T4 | |
additional information | DNA polymerase is not inhibited by diallyl trisulfide, diallyl tetrasulfide, and diallyl pentasulfide | Thermus aquaticus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00118 | - |
deoxynucleoside triphosphate | DNA polymerase lambda, in 50 mM Tris-HCl (pH 7.5), 1 mM dithiothreitol, 50% (v/v) glycerol, and 0.1 mM EDTA, at 37°C | Homo sapiens | |
0.00305 | - |
deoxynucleoside triphosphate | DNA polymerase beta, in 50 mM Tris-HCl (pH 7.5), 1 mM dithiothreitol, 50% (v/v) glycerol, and 0.1 mM EDTA, at 37°C | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Brassica oleracea | - |
- |
- |
Drosophila melanogaster | - |
- |
- |
Escherichia coli | - |
- |
- |
Homo sapiens | - |
- |
- |
Oncorhynchus masou | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Tequatrovirus T4 | - |
- |
- |
Thermus aquaticus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxynucleoside triphosphate + DNAn | - |
Drosophila melanogaster | diphosphate + DNAn+1 | - |
? | |
deoxynucleoside triphosphate + DNAn | - |
Thermus aquaticus | diphosphate + DNAn+1 | - |
? | |
deoxynucleoside triphosphate + DNAn | - |
Escherichia coli | diphosphate + DNAn+1 | - |
? | |
deoxynucleoside triphosphate + DNAn | - |
Homo sapiens | diphosphate + DNAn+1 | - |
? | |
deoxynucleoside triphosphate + DNAn | - |
Rattus norvegicus | diphosphate + DNAn+1 | - |
? | |
deoxynucleoside triphosphate + DNAn | - |
Bos taurus | diphosphate + DNAn+1 | - |
? | |
deoxynucleoside triphosphate + DNAn | - |
Tequatrovirus T4 | diphosphate + DNAn+1 | - |
? | |
deoxynucleoside triphosphate + DNAn | - |
Brassica oleracea | diphosphate + DNAn+1 | - |
? | |
deoxynucleoside triphosphate + DNAn | - |
Oncorhynchus masou | diphosphate + DNAn+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DNA polymerase | - |
Drosophila melanogaster |
DNA polymerase | - |
Thermus aquaticus |
DNA polymerase | - |
Escherichia coli |
DNA polymerase | - |
Tequatrovirus T4 |
DNA polymerase | - |
Brassica oleracea |
DNA polymerase alpha | - |
Bos taurus |
DNA polymerase beta | - |
Rattus norvegicus |
DNA polymerase delta | - |
Oncorhynchus masou |
DNA polymerase lambda | - |
Homo sapiens |
Klenow fragment | - |
Escherichia coli |
Pol | - |
Thermus aquaticus |
Pol | - |
Tequatrovirus T4 |
pol alpha | - |
Bos taurus |
pol alpha | isozyme | Drosophila melanogaster |
pol beta | - |
Rattus norvegicus |
pol delta | - |
Oncorhynchus masou |
pol delta | isozyme | Drosophila melanogaster |
POl epsilon | isozyme | Drosophila melanogaster |
Pol I | isozyme | Escherichia coli |
Pol I | isozyme | Brassica oleracea |
Pol II | isozyme | Brassica oleracea |
Pol lambda | X family DNA polymerase | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | Allium sativum extract has a KI value of 0.00368 mM using DNA polymerase beta, in 50 mM Tris-HCl (pH 7.5), 1 mM dithiothreitol, 50% (v/v) glycerol, and 0.1 mM EDTA, at 37°C | Rattus norvegicus | |
additional information | - |
additional information | Allium sativum extract has an KI value of 0.0112 mM using DNA polymerase lambda, in 50 mM Tris-HCl (pH 7.5), 1 mM dithiothreitol, 50% (v/v) glycerol, and 0.1 mM EDTA, at 37°C | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
Allium sativum extract has an IC50 of 0.0345 mM, using DNA polymerase lambda in 50 mM Tris-HCl (pH 7.5), 1 mM dithiothreitol, 50% (v/v) glycerol, and 0.1 mM EDTA, at 37°C | Homo sapiens | additional information | |
additional information | - |
Allium sativum extract has an IC50 value of 0.0097 mM using DNA polymerase beta, in 50 mM Tris-HCl (pH 7.5), 1 mM dithiothreitol, 50% (v/v) glycerol, and 0.1 mM EDTA, at 37°C | Rattus norvegicus | additional information | |
0.115 | - |
DNA polymerase beta, in 50 mM Tris-HCl (pH 7.5), 1 mM dithiothreitol, 50% (v/v) glycerol, and 0.1 mM EDTA, at 37°C | Rattus norvegicus | diallyl trisulfide | |
0.146 | - |
DNA polymerase lambda, in 50 mM Tris-HCl (pH 7.5), 1 mM dithiothreitol, 50% (v/v) glycerol, and 0.1 mM EDTA, at 37°C | Homo sapiens | diallyl trisulfide |