Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-deoxyrubralactone | potent inhibitor of isozymes pol kappa, pol lambda, pol iota, and pol eta, but does not inhibit DNA polymerase isozymes pol delta, pol epsilon, and pol gamma | Homo sapiens | |
1-deoxyrubralactone | potent inhibitor | Rattus norvegicus | |
additional information | not inhibited by 1-deoxyrubralactone and talaroflavone | Bos taurus | |
additional information | not inhibited by 1-deoxyrubralactone and talaroflavone | Brassica oleracea | |
additional information | not inhibited by 1-deoxyrubralactone and talaroflavone | Escherichia coli | |
additional information | not inhibited by 1-deoxyrubralactone and talaroflavone | Tequatrovirus T4 | |
additional information | not inhibited by 1-deoxyrubralactone and talaroflavone | Thermus aquaticus | |
talaroflavone | - |
Homo sapiens | |
talaroflavone | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Brassica oleracea | - |
- |
- |
Escherichia coli | - |
- |
- |
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Tequatrovirus T4 | - |
- |
- |
Thermus aquaticus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxynucleoside triphosphate + DNAn | - |
Thermus aquaticus | diphosphate + DNAn+1 | - |
? | |
deoxynucleoside triphosphate + DNAn | - |
Escherichia coli | diphosphate + DNAn+1 | - |
? | |
deoxynucleoside triphosphate + DNAn | - |
Homo sapiens | diphosphate + DNAn+1 | - |
? | |
deoxynucleoside triphosphate + DNAn | - |
Rattus norvegicus | diphosphate + DNAn+1 | - |
? | |
deoxynucleoside triphosphate + DNAn | - |
Bos taurus | diphosphate + DNAn+1 | - |
? | |
deoxynucleoside triphosphate + DNAn | - |
Tequatrovirus T4 | diphosphate + DNAn+1 | - |
? | |
deoxynucleoside triphosphate + DNAn | - |
Brassica oleracea | diphosphate + DNAn+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DNA polymerase | - |
Thermus aquaticus |
DNA polymerase | - |
Homo sapiens |
DNA polymerase | - |
Tequatrovirus T4 |
DNA polymerase alpha | - |
Bos taurus |
DNA polymerase alpha | - |
Brassica oleracea |
DNA polymerase beta | - |
Rattus norvegicus |
DNA polymerase beta | - |
Brassica oleracea |
DNA polymerase I | - |
Escherichia coli |
Pol | - |
Thermus aquaticus |
Pol | - |
Tequatrovirus T4 |
pol alpha | - |
Bos taurus |
pol alpha | - |
Brassica oleracea |
pol beta | - |
Rattus norvegicus |
pol beta | - |
Brassica oleracea |
pol delta | isozyme | Homo sapiens |
POl epsilon | isozyme | Homo sapiens |
Pol eta | isozyme | Homo sapiens |
Pol gamma | isozyme | Homo sapiens |
Pol I | - |
Escherichia coli |
pol iota | isozyme | Homo sapiens |
pol kappa | isozyme | Homo sapiens |
Pol lambda | isozyme | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0598 | - |
in 50 mM Tris-HCl (pH 7.5) containing 1 mM dithiothreitol, 50% (v/v) glycerol, and 0.1 mM EDTA, at 37°C | Homo sapiens | 1-deoxyrubralactone |