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Literature summary for 2.7.7.7 extracted from
- 1-deoxyrubralactone, a novel specific inhibitor of families X and Y of eukaryotic DNA polymerases from a fungal strain derived from sea algae (2008), Bioorg. Med. Chem., 16, 2939-2944.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-deoxyrubralactone | potent inhibitor of isozymes pol kappa, pol lambda, pol iota, and pol eta, but does not inhibit DNA polymerase isozymes pol delta, pol epsilon, and pol gamma | Homo sapiens |  |
| 1-deoxyrubralactone | potent inhibitor | Rattus norvegicus | |
| additional information | not inhibited by 1-deoxyrubralactone and talaroflavone | Bos taurus | |
| additional information | not inhibited by 1-deoxyrubralactone and talaroflavone | Brassica oleracea | |
| additional information | not inhibited by 1-deoxyrubralactone and talaroflavone | Escherichia coli | |
| additional information | not inhibited by 1-deoxyrubralactone and talaroflavone | Tequatrovirus T4 | |
| additional information | not inhibited by 1-deoxyrubralactone and talaroflavone | Thermus aquaticus | |
| talaroflavone | - |
Homo sapiens | |
| talaroflavone | - |
Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Brassica oleracea | - |
- |
- |
| Escherichia coli | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Tequatrovirus T4 | - |
- |
- |
| Thermus aquaticus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| deoxynucleoside triphosphate + DNAn | - |
Thermus aquaticus | diphosphate + DNAn+1 | - |
? | |
| deoxynucleoside triphosphate + DNAn | - |
Escherichia coli | diphosphate + DNAn+1 | - |
? | |
| deoxynucleoside triphosphate + DNAn | - |
Homo sapiens | diphosphate + DNAn+1 | - |
? | |
| deoxynucleoside triphosphate + DNAn | - |
Rattus norvegicus | diphosphate + DNAn+1 | - |
? | |
| deoxynucleoside triphosphate + DNAn | - |
Bos taurus | diphosphate + DNAn+1 | - |
? | |
| deoxynucleoside triphosphate + DNAn | - |
Tequatrovirus T4 | diphosphate + DNAn+1 | - |
? | |
| deoxynucleoside triphosphate + DNAn | - |
Brassica oleracea | diphosphate + DNAn+1 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DNA polymerase | - |
Thermus aquaticus |
| DNA polymerase | - |
Homo sapiens |
| DNA polymerase | - |
Tequatrovirus T4 |
| DNA polymerase alpha | - |
Bos taurus |
| DNA polymerase alpha | - |
Brassica oleracea |
| DNA polymerase beta | - |
Rattus norvegicus |
| DNA polymerase beta | - |
Brassica oleracea |
| DNA polymerase I | - |
Escherichia coli |
| Pol | - |
Thermus aquaticus |
| Pol | - |
Tequatrovirus T4 |
| pol alpha | - |
Bos taurus |
| pol alpha | - |
Brassica oleracea |
| pol beta | - |
Rattus norvegicus |
| pol beta | - |
Brassica oleracea |
| pol delta | isozyme | Homo sapiens |
| POl epsilon | isozyme | Homo sapiens |
| Pol eta | isozyme | Homo sapiens |
| Pol gamma | isozyme | Homo sapiens |
| Pol I | - |
Escherichia coli |
| pol iota | isozyme | Homo sapiens |
| pol kappa | isozyme | Homo sapiens |
| Pol lambda | isozyme | Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0598 | - |
in 50 mM Tris-HCl (pH 7.5) containing 1 mM dithiothreitol, 50% (v/v) glycerol, and 0.1 mM EDTA, at 37°C | Homo sapiens | 1-deoxyrubralactone | |
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Release 2023.1 (January 2023)
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