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Literature summary for 2.7.7.7 extracted from

  • Kuchta, R.D.; Ilsley, D.; Kravig, K.D.; Schubert, S.; Harris, B.
    Inhibition of DNA primase and polymerase alpha by arabinofuranosylnucleoside triphosphates and related compounds (1992), Biochemistry, 31, 4720-4728.
    View publication on PubMed
Search for more literature for 2.7.7.7

Inhibitors

Inhibitors Comment Organism Structure
Arabinofuranosylnucleoside triphosphates and related compounds Bos taurus
Dideoxyadenosine triphosphate weak inhibitor Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
deoxynucleoside triphosphate + DNAn Bos taurus
-
 diphosphate + DNAn+1
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 polymerase alpha
-

Purification (Commentary)

Purification (Comment) Organism
calf Bos taurus
polymerase alpha Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
thymus
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
 Bos taurus diphosphate + DNAn+1
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.071
-
 Dideoxyadenosine triphosphate pH 7.5, 37°C Bos taurus