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Literature summary for 2.7.7.7 extracted from

  • Bambara, R.A.; Jessee, C.B.
    Properties of DNA polymerases delta and epsilon, and their roles in eukaryotic DNA replication (1991), Biochim. Biophys. Acta, 1088, 11-24.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
dimethyl sulfoxide stimulates DNA polymerase alpha and delta, inhibits human DNA polymerase epsilon Mammalia
dimethyl sulfoxide stimulates DNA polymerase alpha and delta, inhibits human DNA polymerase epsilon Mus musculus
dimethyl sulfoxide stimulates DNA polymerase alpha and delta, inhibits human DNA polymerase epsilon Homo sapiens
dimethyl sulfoxide stimulates DNA polymerase alpha and delta, inhibits human DNA polymerase epsilon Bos taurus
dimethyl sulfoxide stimulates DNA polymerase alpha and delta, inhibits human DNA polymerase epsilon Oryctolagus cuniculus
proliferating cell nuclear antigen PCNA, specific auxiliary factor stimulating DNA polymerase delta Mammalia
proliferating cell nuclear antigen PCNA, specific auxiliary factor stimulating DNA polymerase delta Mus musculus
proliferating cell nuclear antigen PCNA, specific auxiliary factor stimulating DNA polymerase delta Homo sapiens
proliferating cell nuclear antigen PCNA, specific auxiliary factor stimulating DNA polymerase delta Bos taurus
proliferating cell nuclear antigen PCNA, specific auxiliary factor stimulating DNA polymerase delta Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate inhibition of DNA polymerase alpha at 100fold lower concentration than DNA polymerase delta Bos taurus
2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate inhibition of DNA polymerase alpha at 100fold lower concentration than DNA polymerase delta Homo sapiens
2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate inhibition of DNA polymerase alpha at 100fold lower concentration than DNA polymerase delta Mammalia
2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate inhibition of DNA polymerase alpha at 100fold lower concentration than DNA polymerase delta Mus musculus
2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate inhibition of DNA polymerase alpha at 100fold lower concentration than DNA polymerase delta Oryctolagus cuniculus
aphidicolin DNA polymerase alpha; DNA polymerase delta; DNA polymerase epsilon Bos taurus
aphidicolin DNA polymerase alpha; DNA polymerase delta; DNA polymerase epsilon Homo sapiens
aphidicolin DNA polymerase alpha; DNA polymerase delta; DNA polymerase epsilon Mammalia
aphidicolin DNA polymerase alpha; DNA polymerase delta; DNA polymerase epsilon Mus musculus
aphidicolin DNA polymerase alpha; DNA polymerase delta; DNA polymerase epsilon Oryctolagus cuniculus
aphidicolin
-
Saccharomyces cerevisiae
Carbonyldiphosphonate polymerase delta and epsilon Bos taurus
Carbonyldiphosphonate
-
Homo sapiens
Carbonyldiphosphonate
-
Mammalia
Carbonyldiphosphonate
-
Mus musculus
Carbonyldiphosphonate
-
Oryctolagus cuniculus
Dideoxynucleoside 5'-triphosphate polymerase epsilon, slightly sensitive Bos taurus
Dideoxynucleoside 5'-triphosphate polymerase epsilon, slightly sensitive Homo sapiens
Dideoxynucleoside 5'-triphosphate polymerase epsilon, slightly sensitive Mammalia
Dideoxynucleoside 5'-triphosphate polymerase epsilon, slightly sensitive Mus musculus
Dideoxynucleoside 5'-triphosphate polymerase epsilon, slightly sensitive Oryctolagus cuniculus
dimethyl sulfoxide stimulates DNA polymerase alpha and delta, inhibits human DNA polymerase epsilon Homo sapiens
N2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-triphosphate inhibition of DNA polymerase alpha at 100fold; lower concentration than DNA polymerase delta Bos taurus
N2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-triphosphate inhibition of DNA polymerase alpha at 100fold; lower concentration than DNA polymerase delta Homo sapiens
N2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-triphosphate inhibition of DNA polymerase alpha at 100fold; lower concentration than DNA polymerase delta Mammalia
N2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-triphosphate inhibition of DNA polymerase alpha at 100fold; lower concentration than DNA polymerase delta Mus musculus
N2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-triphosphate inhibition of DNA polymerase alpha at 100fold; lower concentration than DNA polymerase delta Oryctolagus cuniculus
N2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-triphosphate
-
Saccharomyces cerevisiae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
48000
-
x * 180000 + x * 86000 + x * 58000 + x * 48000, polymerase alpha Saccharomyces cerevisiae
49000
-
x * 60000 + x * 49000, SDS-PAGE Bos taurus
50000
-
1 * 125000 + 1 * 50000, DNA polymerase delta Mus musculus
55000
-
x * 125000 + x * 55000, polymerase delta Saccharomyces cerevisiae
58000
-
x * 180000 + x * 86000 + x * 58000 + x * 48000, polymerase alpha Saccharomyces cerevisiae
60000
-
x * 60000 + x * 49000, SDS-PAGE Bos taurus
86000
-
x * 180000 + x * 86000 + x * 58000 + x * 48000, polymerase alpha Saccharomyces cerevisiae
122000
-
DNA polymerase epsilon, gel filtration Oryctolagus cuniculus
125000
-
x * 125000 + x * 55000, polymerase delta Saccharomyces cerevisiae
125000
-
1 * 125000 + 1 * 50000, DNA polymerase delta Mus musculus
170000
-
-
Saccharomyces cerevisiae
170000
-
-
Bos taurus
170000
-
DNA polymerase epsilon Homo sapiens
178000
-
DNA polymerase delta Mus musculus
180000
-
x * 180000 + x * 86000 + x * 58000 + x * 48000, polymerase alpha Saccharomyces cerevisiae
200000
-
polymerase delta, gel filtration Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
deoxynucleoside triphosphate + DNAn Mammalia
-
diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn Mus musculus
-
diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn Homo sapiens
-
diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn Saccharomyces cerevisiae
-
diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn Bos taurus
-
diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn Oryctolagus cuniculus
-
diphosphate + DNAn+1
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-
Mammalia
-
-
-
Mus musculus
-
-
-
Oryctolagus cuniculus
-
-
-
Saccharomyces cerevisiae
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow
-
Oryctolagus cuniculus
-
placenta
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
Mammalia diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn
-
Mus musculus diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn
-
Homo sapiens diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn
-
Saccharomyces cerevisiae diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn
-
Bos taurus diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn
-
Oryctolagus cuniculus diphosphate + DNAn+1
-
?

Subunits

Subunits Comment Organism
?
-
Mammalia
? x * 125000 + x * 55000, polymerase delta Saccharomyces cerevisiae
? x * 180000 + x * 86000 + x * 58000 + x * 48000, polymerase alpha Saccharomyces cerevisiae
? x * 60000 + x * 49000, SDS-PAGE Bos taurus
dimer
-
Homo sapiens
dimer
-
Saccharomyces cerevisiae
dimer
-
Bos taurus
dimer 1 * 125000 + 1 * 50000, DNA polymerase delta Mus musculus
monomer
-
Bos taurus
monomer 1 * 170000, DNA polymerase epsilon Homo sapiens