Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dimethyl sulfoxide | stimulates DNA polymerase alpha and delta, inhibits human DNA polymerase epsilon | Mammalia | |
dimethyl sulfoxide | stimulates DNA polymerase alpha and delta, inhibits human DNA polymerase epsilon | Mus musculus | |
dimethyl sulfoxide | stimulates DNA polymerase alpha and delta, inhibits human DNA polymerase epsilon | Homo sapiens | |
dimethyl sulfoxide | stimulates DNA polymerase alpha and delta, inhibits human DNA polymerase epsilon | Bos taurus | |
dimethyl sulfoxide | stimulates DNA polymerase alpha and delta, inhibits human DNA polymerase epsilon | Oryctolagus cuniculus | |
proliferating cell nuclear antigen | PCNA, specific auxiliary factor stimulating DNA polymerase delta | Mammalia | |
proliferating cell nuclear antigen | PCNA, specific auxiliary factor stimulating DNA polymerase delta | Mus musculus | |
proliferating cell nuclear antigen | PCNA, specific auxiliary factor stimulating DNA polymerase delta | Homo sapiens | |
proliferating cell nuclear antigen | PCNA, specific auxiliary factor stimulating DNA polymerase delta | Bos taurus | |
proliferating cell nuclear antigen | PCNA, specific auxiliary factor stimulating DNA polymerase delta | Oryctolagus cuniculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate | inhibition of DNA polymerase alpha at 100fold lower concentration than DNA polymerase delta | Bos taurus | |
2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate | inhibition of DNA polymerase alpha at 100fold lower concentration than DNA polymerase delta | Homo sapiens | |
2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate | inhibition of DNA polymerase alpha at 100fold lower concentration than DNA polymerase delta | Mammalia | |
2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate | inhibition of DNA polymerase alpha at 100fold lower concentration than DNA polymerase delta | Mus musculus | |
2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate | inhibition of DNA polymerase alpha at 100fold lower concentration than DNA polymerase delta | Oryctolagus cuniculus | |
aphidicolin | DNA polymerase alpha; DNA polymerase delta; DNA polymerase epsilon | Bos taurus | |
aphidicolin | DNA polymerase alpha; DNA polymerase delta; DNA polymerase epsilon | Homo sapiens | |
aphidicolin | DNA polymerase alpha; DNA polymerase delta; DNA polymerase epsilon | Mammalia | |
aphidicolin | DNA polymerase alpha; DNA polymerase delta; DNA polymerase epsilon | Mus musculus | |
aphidicolin | DNA polymerase alpha; DNA polymerase delta; DNA polymerase epsilon | Oryctolagus cuniculus | |
aphidicolin | - |
Saccharomyces cerevisiae | |
Carbonyldiphosphonate | polymerase delta and epsilon | Bos taurus | |
Carbonyldiphosphonate | - |
Homo sapiens | |
Carbonyldiphosphonate | - |
Mammalia | |
Carbonyldiphosphonate | - |
Mus musculus | |
Carbonyldiphosphonate | - |
Oryctolagus cuniculus | |
Dideoxynucleoside 5'-triphosphate | polymerase epsilon, slightly sensitive | Bos taurus | |
Dideoxynucleoside 5'-triphosphate | polymerase epsilon, slightly sensitive | Homo sapiens | |
Dideoxynucleoside 5'-triphosphate | polymerase epsilon, slightly sensitive | Mammalia | |
Dideoxynucleoside 5'-triphosphate | polymerase epsilon, slightly sensitive | Mus musculus | |
Dideoxynucleoside 5'-triphosphate | polymerase epsilon, slightly sensitive | Oryctolagus cuniculus | |
dimethyl sulfoxide | stimulates DNA polymerase alpha and delta, inhibits human DNA polymerase epsilon | Homo sapiens | |
N2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-triphosphate | inhibition of DNA polymerase alpha at 100fold; lower concentration than DNA polymerase delta | Bos taurus | |
N2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-triphosphate | inhibition of DNA polymerase alpha at 100fold; lower concentration than DNA polymerase delta | Homo sapiens | |
N2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-triphosphate | inhibition of DNA polymerase alpha at 100fold; lower concentration than DNA polymerase delta | Mammalia | |
N2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-triphosphate | inhibition of DNA polymerase alpha at 100fold; lower concentration than DNA polymerase delta | Mus musculus | |
N2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-triphosphate | inhibition of DNA polymerase alpha at 100fold; lower concentration than DNA polymerase delta | Oryctolagus cuniculus | |
N2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-triphosphate | - |
Saccharomyces cerevisiae |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
48000 | - |
x * 180000 + x * 86000 + x * 58000 + x * 48000, polymerase alpha | Saccharomyces cerevisiae |
49000 | - |
x * 60000 + x * 49000, SDS-PAGE | Bos taurus |
50000 | - |
1 * 125000 + 1 * 50000, DNA polymerase delta | Mus musculus |
55000 | - |
x * 125000 + x * 55000, polymerase delta | Saccharomyces cerevisiae |
58000 | - |
x * 180000 + x * 86000 + x * 58000 + x * 48000, polymerase alpha | Saccharomyces cerevisiae |
60000 | - |
x * 60000 + x * 49000, SDS-PAGE | Bos taurus |
86000 | - |
x * 180000 + x * 86000 + x * 58000 + x * 48000, polymerase alpha | Saccharomyces cerevisiae |
122000 | - |
DNA polymerase epsilon, gel filtration | Oryctolagus cuniculus |
125000 | - |
x * 125000 + x * 55000, polymerase delta | Saccharomyces cerevisiae |
125000 | - |
1 * 125000 + 1 * 50000, DNA polymerase delta | Mus musculus |
170000 | - |
- |
Saccharomyces cerevisiae |
170000 | - |
- |
Bos taurus |
170000 | - |
DNA polymerase epsilon | Homo sapiens |
178000 | - |
DNA polymerase delta | Mus musculus |
180000 | - |
x * 180000 + x * 86000 + x * 58000 + x * 48000, polymerase alpha | Saccharomyces cerevisiae |
200000 | - |
polymerase delta, gel filtration | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxynucleoside triphosphate + DNAn | Mammalia | - |
diphosphate + DNAn+1 | - |
? | |
deoxynucleoside triphosphate + DNAn | Mus musculus | - |
diphosphate + DNAn+1 | - |
? | |
deoxynucleoside triphosphate + DNAn | Homo sapiens | - |
diphosphate + DNAn+1 | - |
? | |
deoxynucleoside triphosphate + DNAn | Saccharomyces cerevisiae | - |
diphosphate + DNAn+1 | - |
? | |
deoxynucleoside triphosphate + DNAn | Bos taurus | - |
diphosphate + DNAn+1 | - |
? | |
deoxynucleoside triphosphate + DNAn | Oryctolagus cuniculus | - |
diphosphate + DNAn+1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Homo sapiens | - |
- |
- |
Mammalia | - |
- |
- |
Mus musculus | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone marrow | - |
Oryctolagus cuniculus | - |
placenta | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxynucleoside triphosphate + DNAn | - |
Mammalia | diphosphate + DNAn+1 | - |
? | |
deoxynucleoside triphosphate + DNAn | - |
Mus musculus | diphosphate + DNAn+1 | - |
? | |
deoxynucleoside triphosphate + DNAn | - |
Homo sapiens | diphosphate + DNAn+1 | - |
? | |
deoxynucleoside triphosphate + DNAn | - |
Saccharomyces cerevisiae | diphosphate + DNAn+1 | - |
? | |
deoxynucleoside triphosphate + DNAn | - |
Bos taurus | diphosphate + DNAn+1 | - |
? | |
deoxynucleoside triphosphate + DNAn | - |
Oryctolagus cuniculus | diphosphate + DNAn+1 | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | - |
Mammalia |
? | x * 125000 + x * 55000, polymerase delta | Saccharomyces cerevisiae |
? | x * 180000 + x * 86000 + x * 58000 + x * 48000, polymerase alpha | Saccharomyces cerevisiae |
? | x * 60000 + x * 49000, SDS-PAGE | Bos taurus |
dimer | - |
Homo sapiens |
dimer | - |
Saccharomyces cerevisiae |
dimer | - |
Bos taurus |
dimer | 1 * 125000 + 1 * 50000, DNA polymerase delta | Mus musculus |
monomer | - |
Bos taurus |
monomer | 1 * 170000, DNA polymerase epsilon | Homo sapiens |