Any feedback?
Literature summary for 2.7.7.6 extracted from
- TFB2 is a transient component of the catalytic site of the human mitochondrial RNA polymerase (2009), Cell, 139, 934-944.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| TFB2 | the essential initiation factor forms a network of interactions with DNA near the transcription start site and facilitates promoter melting but may not be essential for promoter recognition, TFB2 bridges upstream and downstream promoter contacts of the initiation complex, mapping of TFB2-DNA interactions at the transcription start site, overview | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of the N-terminally His6-tagged intein fusion mitoRNAP protein | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| G711K/N926S/N1103S/N1117S | site-directed mutagenesis, the mutant mitoRNAP that lacks four natural hydroxylamine cleavage sites | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | molecular mechanisms of transcription regulation in mitochondria, molecular organization of the human mitochondrial transcription initiation complex, overview | ? | - |
? |  |
| nucleoside triphosphate + RNAn | Homo sapiens | - |
diphosphate + RNAn+1 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | molecular mechanisms of transcription regulation in mitochondria, molecular organization of the human mitochondrial transcription initiation complex, overview | Homo sapiens | ? | - |
? | |
| nucleoside triphosphate + RNAn | - |
Homo sapiens | diphosphate + RNAn+1 | - |
? | |
| nucleoside triphosphate + RNAn | template is DNA | Homo sapiens | diphosphate + RNAn+1 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | - |
Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| mitoRNAP | - |
Homo sapiens |
| More | the enzyme belongs to the single-subunit, T7-like mitochondrial RNAP family | Homo sapiens |
| RNA polymerase | - |
Homo sapiens |
| RNAP | - |
Homo sapiens |
| T7 RNAP | - |
Homo sapiens |
| T7-like RNA polymerase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 35 | - |
assay at | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
