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Literature summary for 2.7.7.56 extracted from

  • Wen, T.; Oussenko, I.A.; Pellegrini, O.; Bechhofer, D.H.; Condon, C.
    Ribonuclease PH plays a major role in the exonucleolytic maturation of CCA-containing tRNA precursors in Bacillus subtilis (2005), Nucleic Acids Res., 33, 3636-3643.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
additional information the enzyme appears to be sensitive to the CCA motif and is surprisingly slow to remove the last nucleotide to generate the functional tRNA Bacillus subtilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
tRNAn+1 + phosphate Bacillus subtilis plays a major role in the exonucleolytic maturation of CCA-containing tRNA precursors, degradation of the last few nucleotides before the acceptor stem tRNAn + a nucleoside diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
recombinant
-

Purification (Commentary)

Purification (Comment) Organism
recombinant Bacillus subtilis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
tRNAn+1 + phosphate
-
Bacillus subtilis tRNAn + a nucleoside diphosphate
-
?
tRNAn+1 + phosphate plays a major role in the exonucleolytic maturation of CCA-containing tRNA precursors, degradation of the last few nucleotides before the acceptor stem Bacillus subtilis tRNAn + a nucleoside diphosphate
-
?

Synonyms

Synonyms Comment Organism
RNase PH
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Bacillus subtilis