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Literature summary for 2.7.7.53 extracted from

  • Mori, S.; Kim, H.; Rimbara, E.; Arakawa, Y.; Shibayama, K.
    Roles of Ala-149 in the catalytic activity of diadenosine tetraphosphate phosphorylase from Mycobacterium tuberculosis H37Rv (2015), Biosci. Biotechnol. Biochem., 79, 236-238.
    View publication on PubMed
Search for more literature for 2.7.7.53

Protein Variants

Protein Variants Comment Organism
A149Del an Ala149 deletion mutant displays substrate specificity for diadenosine 5',5'''-P1,P5-pentaphosphate and is inactive on Ap4A and other substrates utilized by the wild-type enzyme Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WMK9
-
-
Mycobacterium tuberculosis H37Rv P9WMK9
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
P1,P3-bis(5'-adenosyl) triphosphate + phosphate wild-type, 19% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 29%, respectively Mycobacterium tuberculosis 2 ADP
-
 ?
P1,P4-bis(5'-adenosyl)tetraphosphate + phosphate
-
 Mycobacterium tuberculosis ADP + ATP
-
 ?
P1,P4-bis(5'-adenosyl)tetraphosphate + phosphate
-
 Mycobacterium tuberculosis H37Rv ADP + ATP
-
 ?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate wild-type, 107% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 53%, respectively Mycobacterium tuberculosis GTP + GDP
-
 ?
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate wild-type, 107% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 53%, respectively Mycobacterium tuberculosis H37Rv GTP + GDP
-
 ?
P1,P5-bis(5'-adenosyl)pentaphosphate + phosphate wild-type, 106% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 290%, respectively Mycobacterium tuberculosis ?
-
 ?
P1,P5-bis(5'-adenosyl)pentaphosphate + phosphate wild-type, 106% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 290%, respectively Mycobacterium tuberculosis H37Rv ?
-
 ?
P1,P5-bis(5'-guanosyl)pentaphosphate + phosphate wild-type, 106% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 95%, respectively Mycobacterium tuberculosis ?
-
 ?
P1,P6-bis(5'-adenosyl)hexaphosphate + phosphate wild-type, 25% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, very poor substrate for mutant A149Del, respectively Mycobacterium tuberculosis ?
-
 ?
P1,P6-bis(5'-adenosyl)hexaphosphate + phosphate wild-type, 25% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, very poor substrate for mutant A149Del, respectively Mycobacterium tuberculosis H37Rv ?
-
 ?
P1-(5'-adenosyl)P4-(5'-guanosyl) tetraphosphate + phosphate wild-type, 100% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 67%, respectively Mycobacterium tuberculosis ATP + GDP
-
 ?
P1-(5'-adenosyl)P4-(5'-guanosyl) tetraphosphate + phosphate wild-type, 100% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 67%, respectively Mycobacterium tuberculosis H37Rv ATP + GDP
-
 ?

Synonyms

Synonyms Comment Organism
AP-4-A phosphorylase
-
 Mycobacterium tuberculosis
Ap4A phosphorylase
-
 Mycobacterium tuberculosis