Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.7.49 extracted from

  • Boojamra, C.G.; Mackman, R.L.; Markevitch, D.Y.; Prasad, V.; Ray, A.S.; Douglas, J.; Grant, D.; Kim, C.U.; Cihlar, T.
    Synthesis and anti-HIV activity of GS-9148 (2-Fd4AP), a novel nucleoside phosphonate HIV reverse transcriptase inhibitor (2008), Bioorg. Med. Chem. Lett., 18, 1120-1123.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
K65R mutant maintains a susceptibility to GS-9148 that is similar to wild type enzyme Human immunodeficiency virus 1
M184V mutant maintains a susceptibility to GS-9148 that is similar to wild type enzyme Human immunodeficiency virus 1

Inhibitors

Inhibitors Comment Organism Structure
([[(2R,5R)-5-(6-amino-7H-purin-7-yl)-2,5-dihydrofuran-2-yl]oxy]methyl)phosphonic acid
-
Human immunodeficiency virus 1
([[(2R,5R)-5-(6-amino-7H-purin-7-yl)-4-fluoro-2,5-dihydrofuran-2-yl]oxy]methyl)phosphonic acid
-
Human immunodeficiency virus 1
([[(2S,5S)-5-(6-amino-7H-purin-7-yl)-2,5-dihydrofuran-2-yl]oxy]methyl)phosphonic acid
-
Human immunodeficiency virus 1
GS-9148 2'-Fd4AP Human immunodeficiency virus 1
Tenofovir
-
Human immunodeficiency virus 1

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
Human immunodeficiency virus 1 diphosphate + DNAn+1
-
?

Synonyms

Synonyms Comment Organism
reverse transcriptase
-
Human immunodeficiency virus 1