Protein Variants | Comment | Organism |
---|---|---|
K65R | exhibits an 8-fold resistance to ddATP. 22fold decrease of the catalytic rate constant | Human immunodeficiency virus 1 |
K65R/L74V | 84fold decrease of the catalytic rate constant. Virus replication capacity is severely impaired relative to wild-type enzyme. Poor ability of K65R/L74V RT to use natural nucleotides relative to wild-type enzyme: 15% that of wild-type enzyme for dATP, 36% for dGTP, 50% for dTTP, and 25% for dCTP | Human immunodeficiency virus 1 |
Organism | UniProt | Comment | Textmining |
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Human immunodeficiency virus 1 | - |
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