Literature summary for 2.7.7.49 extracted from

Lebedeva, N.A.; Seredina, T.A.; Silnikov, V.N.; Abramova, T.V.; Levina, A.S.; Khodyreva, S.N.; Rechkunova, N.I.; Lavrik, O.I.
Analysis of interactions of DNA polymerase beta and reverse transcriptases of human immunodeficiency and mouse leukemia viruses with dNTP analogs containing a modified sugar residue (2005), Biochemistry, 70, 1-7.

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Inhibitors

Inhibitors	Comment	Organism	Structure
morpholinocytosine triphosphate	-	Human immunodeficiency virus 1

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
additional information	-	additional information	-	Human immunodeficiency virus 1

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Human immunodeficiency virus 1
Mn2+	substitution of Mg2+ by Mn2+ increases the efficiency of incorporation of dNTP analogs	Human immunodeficiency virus 1

Organism

Organism	UniProt	Comment	Textmining
Human immunodeficiency virus 1	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
deoxynucleoside triphosphate + DNAn	-	Human immunodeficiency virus 1	diphosphate + DNAn+1	-	?

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
additional information	-	additional information	-	Human immunodeficiency virus 1

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Release 2023.1 (January 2023)