Literature summary for 2.7.7.49 extracted from

Kaushik, N.; Harris, D.; Rege, N.; Modak, M.J.; Yadav, P.N.S.; Pandey, V.N.
Role of glutamine 151 of human immunodeficiency virus type-1 reverse transcriptase in RNA-directed DNA synthesis (1997), Biochemistry, 36, 14430-14438.

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Protein Variants

Protein Variants	Comment	Organism
Q151A	severe reduction in the polymerase activity withoput any significant effect on the affinity for dNTP substrate. The mutant is nearly devoid of diphosphorolytic activity on a RNA/primer-binding-site template-primer	Human immunodeficiency virus 1

Organism

Organism	UniProt	Comment	Textmining
Human immunodeficiency virus 1	P03366	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
deoxynucleoside triphosphate + DNAn	with RNA-directed DNA synthesis, the rate-limiting step occurs after the phosphodiester bond formation while with DNA template it occurs at the dNTP binding step	Human immunodeficiency virus 1	diphosphate + DNAn+1	-	?

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Release 2023.1 (January 2023)