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Literature summary for 2.7.7.49 extracted from

  • Ono, K.; Ogasawara, M.; Iwata, Y.; Nakane, H.; Fujii, T.; Sawai, K.; Saneyoshi, M.
    Inhibition of reverse transcriptase activity by 2,3-dideoxythymidine 5-triphosphate and its derivatives modified on the 3 position (1986), Biochem. Biophys. Res. Commun., 140, 498-507.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2',3'-dideoxythymidine 5'-triphosphate Mn2+ is requisite for the compound to exhibit inhibition, competitive with dTTP Rauscher murine leukemia virus
2'-deoxyxylofuranosylthymidine 5'-triphosphate Mn2+ is requisite for the compound to exhibit inhibition, competitive with dTTP Rauscher murine leukemia virus
3'-Azido-2',3'-dideoxythymidine 5'-triphosphate Mn2+ is requisite for the compound to exhibit inhibition, competitive with dTTP Rauscher murine leukemia virus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.03
-
dTTP pH 8.5, 37°C Rauscher murine leukemia virus

Organism

Organism UniProt Comment Textmining
Rauscher murine leukemia virus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
Rauscher murine leukemia virus diphosphate + DNAn+1
-
?
dTTP + poly(rA)/(dT)18
-
Rauscher murine leukemia virus ?
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0018
-
3'-Azido-2',3'-dideoxythymidine 5'-triphosphate pH 8.5, 37°C Rauscher murine leukemia virus
0.0093
-
2',3'-dideoxythymidine 5'-triphosphate pH 8.5, 37°C Rauscher murine leukemia virus
0.0163
-
2'-deoxyxylofuranosylthymidine 5'-triphosphate pH 8.5, 37°C Rauscher murine leukemia virus